Potential of Mesenchymal Stem Cells in Anti-Cancer Therapies.

Current Stem Cell Research & Therapy
Milena Kostadinova, Milena Mourdjeva

Abstract

Mesenchymal stem/stromal cells (MSCs) are localized throughout the adult body as a small population in the stroma of the tissue concerned. In injury, tissue damage, or tumor formation, they are activated and leave their niche to migrate to the site of injury, where they release a plethora of growth factors, cytokines, and other bioactive molecules. With the accumulation of data about the interaction between MSCs and tumor cells, the dualistic role of MSCs remains unclear. However, a large number of studies have demonstrated the natural anti-tumor properties inherent in MSCs, so this is the basis for intensive research for new methods using MSCs as a tool to suppress cancer cell development. This review focuses specifically on advanced approaches in modifying MSCs to become a powerful, precision- targeted tool for killing cancer cells, but not normal healthy cells. Suppression of tumor growth by MSCs can be accomplished by inducing apoptosis or cell cycle arrest, suppressing tumor angiogenesis, or blocking mechanisms mediating metastasis. In addition, the chemosensitivity of cancer cells may be increased so that the dose of the chemotherapeutic agent used could be significantly reduced.

References

Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Mar 26, 2003·Cell Death and Differentiation·H N LeBlanc, A Ashkenazi
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Songtao Shi, Stan Gronthos
Nov 4, 2004·Journal of the National Cancer Institute·Matus StudenyMichael Andreeff
Nov 24, 2004·Clinical & Experimental Metastasis·Fernando A FierroJosé J Minguell
Mar 22, 2005·Experimental Cell Research·Ida RasmussonKatarina Le Blanc
Apr 19, 2005·Cancer Research·Akira NakamizoFrederick F Lang
Sep 6, 2005·Blood·Anna CorcioneAntonio Uccelli
Oct 11, 2005·Experimental and Molecular Pathology·Wei ZhuYongchang Chen
Dec 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lauren ClancyFrancis Ka-Ming Chan
Apr 26, 2006·The Journal of Experimental Medicine·Aarif Y KhakooToren Finkel
Mar 17, 2007·Transplantation Proceedings·S SchrepferM P Pelletier
Oct 5, 2007·Nature·Antoine E KarnoubRobert A Weinberg
Dec 7, 2007·Cancer Biology & Therapy·Yan-rong LuJing-qiu Cheng
Mar 26, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xiancheng ChenXia Zhao
Jul 2, 2008·Methods in Molecular Biology·Joost P J J HegmansBart N Lambrecht
Jul 17, 2008·Nature Reviews. Molecular Cell Biology·Matthias Schäfer, Sabine Werner
Nov 14, 2008·Fertility and Sterility·Rumen DimitrovStanimir Kyurkchiev
May 14, 2009·Cancer Research·Michael R LoebingerSam M Janes
Jul 15, 2009·Breast Cancer Research and Treatment·Lyndsay V RhodesMatthew E Burow
Oct 9, 2009·Tissue Engineering. Part C, Methods·Jessica E FrithPaul G Genever
Dec 8, 2009·Nature Cell Biology·Matias OstrowskiClotilde Thery
Feb 19, 2010·Trends in Molecular Medicine·Gwendal Lazennec, Ann Richmond
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Kei ShinagawaKazuaki Chayama
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Thomas J BartoshDarwin J Prockop
Aug 13, 2010·Kidney International·Giovanni CamussiLuigi Biancone
Dec 21, 2010·Journal of Mammary Gland Biology and Neoplasia·Christelle P El-Haibi, Antoine E Karnoub

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Citations

Sep 19, 2020·International Journal of Molecular Sciences·Claudia CavallariMaria Felice Brizzi

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