Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies

European Journal of Medicinal Chemistry
Yiyun ChengTongwen Xu

Abstract

Camptothecin (CPT), a plant alkaloid isolated from Camptotheca acuminata, has an extremely low solubility in aqueous medium, which presents a major challenge during drug formulation in clinical trails. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. Results showed that the aqueous solubility of CPT was significantly increased by PAMAM dendrimers. The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT.

References

Jan 23, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·R X ZhuoZ R Lu
Mar 8, 2000·International Journal of Pharmaceutics·O M MilhemA D'Emanuele
Feb 19, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jichao KangRaymond J Hohl
May 16, 2002·Bioconjugate Chemistry·Omayra L Padilla De JesúsFrancis C Szoka
Jul 23, 2002·Current Opinion in Chemical Biology·Anil K PatriJames R Baker
Jun 6, 2003·International Journal of Pharmaceutics·Parag KolheMary Lieh-Lai
Aug 9, 2003·Drug Development and Industrial Pharmacy·Wenkai TongMartin J D'Souza
Oct 23, 2003·Journal of the American Chemical Society·Paul Furuta, Jean M J Fréchet
May 19, 2004·Journal of Biomaterials Science. Polymer Edition·Sujatha KannanDavid Bassett
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rafael Barreiro-IglesiasCarmen Alvarez-Lorenzo
Aug 12, 2004·Journal of the American Chemical Society·Hui-Ting ChenEric E Simanek
Sep 30, 2004·International Journal of Pharmaceutics·Ann Mari SaeternMartin Brandl
Sep 30, 2004·International Journal of Pharmaceutics·Bharathi DevarakondaMelgardt M de Villiers
Dec 4, 2004·Biomaterials·M BerradaS Lehnert
Jan 29, 2005·Drug Discovery Today·Elizabeth R Gillies, Jean M J Fréchet
Oct 18, 2005·European Journal of Medicinal Chemistry·Cheng Yiyun, Xu Tongwen
Oct 18, 2005·European Journal of Medicinal Chemistry·Cheng YiyunFu Rongqiang
Nov 22, 2005·Advanced Drug Delivery Reviews·Ruth Duncan, Lorella Izzo
Nov 25, 2005·Advanced Drug Delivery Reviews·Sönke Svenson, Donald A Tomalia
Dec 6, 2005·International Journal of Pharmaceutics·Masato WatanabeYoshie Maitani
May 9, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kumi KawanoYoshie Maitani
Jul 18, 2006·Current Medicinal Chemistry·Qing-Yong LiLi-Ping Yao
Jul 28, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Praneet OpanasopitSuwabun Chirachanchai
Mar 6, 2007·European Journal of Medicinal Chemistry·Yiyun ChengTongwen Xu

❮ Previous
Next ❯

Citations

Nov 28, 2013·ACS Chemical Neuroscience·Leyuan XuYue Wu
Apr 11, 2012·Chemical Reviews·Jingjing HuYiyun Cheng
Mar 4, 2014·PloS One·Maria Jimena PrietoSilvia del Valle Alonso
Sep 14, 2012·International Journal of Nanomedicine·A Filipowicz, S Wołowiec
Dec 4, 2012·International Journal of Molecular Sciences·Xiaonan ZhangLei Yang
Apr 8, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Adam BuczkowskiBartlomiej Palecz
Feb 22, 2011·International Journal of Pharmaceutics·Adam BuczkowskiBartlomiej Palecz
Aug 13, 2013·International Journal of Pharmaceutics·S SadekarH Ghandehari
Dec 18, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A LaznickovaP Hermann
Jan 22, 2011·European Journal of Medicinal Chemistry·María Jimena PrietoSilvia del Valle Alonso
Dec 12, 2012·Journal of Bioactive and Compatible Polymers·Khushboo SharmaHu Yang
May 12, 2018·Nature Communications·Pierre-Alain BurnoufSteve R Roffler
Sep 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingyi Zhu, Xiangyang Shi
Nov 21, 2017·Chemical Society Reviews·Serge MignaniJean-Pierre Majoral

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.