Potential of silk sericin based nanofibrous mats for wound dressing applications

Materials Science & Engineering. C, Materials for Biological Applications
Sween GilotraBiman B Mandal

Abstract

Wound dressing developed using bioactive materials has been a current area of research for treating chronic non-healing wounds owing to its high demand. Here, we report the fabrication and evaluation of nanofibrous matrix based wound dressings using biopolymer poly(vinyl alcohol) (PVA) incorporated with silk sericin (SS). SS extracted from the cocoons of mulberry variety Bombyx mori and non-mulberry variety Antheraea assama has been used to develop two types of blended mats. Herein, SS based nanofibrous dressings fabricated using electrospinning technique were thoroughly characterized and evaluated for wound healing applications. The developed SS based nanofibrous mats ranged from 130 to 160 nm in diameter with micro to nanoporous structure. The dressings were endowed with free radical scavenging capacity, antibacterial activity, swelling capacity, and biocompatibility due to incorporation of SS. Furthermore, murine fibroblasts (L929) and human keratinocytes (HaCaT) cultured on the PVA-SS blended mats showed higher proliferation as compared to pristine PVA mats as observed over a period of 14 days (p ≤ 0.01). The blended mats also showed spread out morphology of cells in comparison to spherical clumps formed on PVA mats. In add...Continue Reading

Citations

Jul 17, 2020·Microscopy Research and Technique·Lu MaMingying Yang
Sep 15, 2020·Expert Opinion on Drug Delivery· Madhukiran DrBrahmeshwar Mishra
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