Potential of Stem Cell-Based Therapy for Ischemic Stroke

Frontiers in Neurology
Hany E MareiAshfaq Shuaib

Abstract

Ischemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells (NSCs), mesenchymal stem cells, embryonic stem cells, and human induced pluripotent stem cell-derived NSCs as treatments for ischemic stroke. The results of these studies are intriguing but many of them have presented conflicting results. Additionally, the mechanism(s) by which engrafted stem/progenitor cells exert their actions are to a large extent unknown. In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. Due to limited/short time window implemented in most of the recorded clinical trials about the use of stem cells as potential therapeutic intervention for stroke, further clinical trials evaluating the efficacy of the intervention in a longer time window after cellular engraftments are still needed.

References

Nov 6, 1998·Science·J A ThomsonJ M Jones
Aug 15, 2002·Cell·Hynek WichterleThomas M Jessell
May 26, 2004·Neuroscience Letters·Mel TohillGiorgio Terenghi
Jun 2, 2005·Annals of Neurology·Oh Young BangGwang Lee
Oct 5, 2006·Brain : a Journal of Neurology·Claudia BühnemannMarcel Dihné
Nov 15, 2006·Transplantation·Sophia K DeanBernard E Tuch
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Tonya BlissGary K Steinberg
Mar 16, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alex ZacharekMichael Chopp
Nov 3, 2007·Journal of Neuroscience Research·Raphael GuzmanGary Steinberg
Mar 1, 2008·Stroke; a Journal of Cerebral Circulation·James C GrottaMichael A Moskowitz
May 13, 2008·Genes, Chromosomes & Cancer·Sheng YangGuang-Xiu Lu
Mar 10, 2009·Biochemical and Biophysical Research Communications·Matthieu SchoenhalsBernard Klein
Apr 21, 2009·Lancet Neurology·Zheng Gang Zhang, Michael Chopp
Jun 18, 2009·Restorative Neurology and Neuroscience·Carlos Suárez-MonteagudoJorge A Bergado
Jul 11, 2009·Nature Biotechnology·Kyoko MiuraShinya Yamanaka
Aug 20, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Benjamin BakondiJeffrey L Spees
Nov 26, 2009·Cancer Research·Davide Ruggero
Jan 16, 2010·The Journal of Biological Chemistry·Yanyan TianZhihua Liu
Mar 11, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hiromi KawaiKoji Abe
Apr 20, 2010·Advances in Cancer Research·Ami AlbihnMarie Arsenian Henriksson
Jul 16, 2010·The American Journal of Surgical Pathology·Lynette M ShollJason L Hornick
Jul 29, 2010·Journal of Cellular Biochemistry·Chui-Yee FongAriff Bongso
Sep 9, 2010·International Journal of Cancer. Journal International Du Cancer·Malek H AsadiYaser Atlasi
Nov 9, 2010·Cell Transplantation·Toru YamashitaKoji Abe
Jan 19, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Koji AbeNobutaka Kawahara

❮ Previous
Next ❯

Citations

Nov 28, 2018·Expert Opinion on Biological Therapy·Diego Incontri AbrahamCesar V Borlongan
Mar 21, 2019·International Immunology·Minako ItoAkihiko Yoshimura
Aug 29, 2020·Journal of Materials Science. Materials in Medicine·Rossana BoniAndrew N Clarkson
Sep 26, 2020·Translational Stroke Research·Meng LuSeyed Esmaeil Khoshnam
May 10, 2018·Frontiers in Neurology·Xiao-Yi XiongQing-Wu Yang
Sep 6, 2018·Experimental Neurobiology·Jeong Seon YoonHaeyoung Suh-Kim
Jan 1, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·D D NamestnikovaK N Yarygin
Sep 27, 2019·Frontiers in Neurology·Héctor Fernández-SusavilaFrancisco Campos
Apr 14, 2020·CNS Neuroscience & Therapeutics·Mohammad Saied SalehiAfshin Borhani-Haghighi
Jun 20, 2018·Drug Delivery and Translational Research·Lucienne N DuruHong Qing
Sep 14, 2018·Clinical Epigenetics·Qingsheng KongYili Wu
Oct 23, 2019·Signal Transduction and Targeted Therapy·Mrinal K GhoshMalini Basu
May 12, 2019·Neuromolecular Medicine·Koteswara Rao NalamoluKrishna Kumar Veeravalli
Jul 30, 2019·The Keio Journal of Medicine·Ryota SakaiMinako Ito
Feb 4, 2019·Current Neurology and Neuroscience Reports·Ania DabrowskiRyan J Felling
Nov 7, 2019·World Journal of Stem Cells·Gui-Long ZhangYe-Zhong Wang
Jan 1, 2020·Translational Stroke Research·Shu-Na WangChao-Yu Miao
Dec 7, 2018·Journal of Cellular Biochemistry·Reza RikhtegarSeyed Kazem Shakouri
Oct 11, 2020·International Journal of Molecular Sciences·Masahito KawaboriKiyohiro Houkin
Oct 25, 2020·Journal of Tissue Engineering and Regenerative Medicine·Martin Bonde JensenMorten Østergaard Andersen
Jan 30, 2021·Journal of Cardiovascular and Thoracic Research·Mehdi HassanpourMohammad Nouri
Jan 25, 2020·Drug Discovery Today·Saeideh NozohouriThomas J Abbruscato
Oct 12, 2020·Signal Transduction and Targeted Therapy·Mrinal K GhoshMalini Basu
Mar 21, 2021·Stroke and Vascular Neurology·Koteswara Rao NalamoluKrishna Kumar Veeravalli
Mar 24, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Robin AugustinePablo Maureira

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
fluorescence-activated cell sorting

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Archives of Internal Medicine
P DormanP Sandercock
BioMed Research International
Lei HaoLei Liu
Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Martin CaprndaPeter Kruzliak
© 2022 Meta ULC. All rights reserved