Potential of vitamin D in treating diabetic cardiomyopathy

Nutrition Research
Ting-Wei LeeYi-Jen Chen

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM), and patients with DM frequently develop diabetic cardiomyopathy. Currently, effective treatments for diabetic cardiomyopathy are limited. Vitamin D exerts pleiotropic effects on the cardiovascular system and is associated with DM. The purpose of this review was to evaluate published research on vitamin D in diabetic cardiomyopathy by searching PubMed databases. Herein, we reviewed vitamin D metabolism; evaluated the molecular, cellular, and neuroendocrine effects in native and bioactive vitamin D; and evaluated the role of vitamin D in treating cardiovascular disease and DM. Some evidence suggests that vitamin D may improve cardiovascular outcomes in diabetes through anti-inflammatory, antioxidative, antihypertrophic, antifibrotic, and antiatherosclerotic activities and by regulating advanced glycation end-product signaling, the renin-angiotensin system, and cardiac metabolism. This clinical and laboratory evidence suggests that vitamin D may be a potential agent in treating diabetic cardiomyopathy. However, using vitamin D entails possible adverse risks of hypercalcemia, hyperphosphatemia, and vascular calcifications...Continue Reading

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Citations

Nov 26, 2015·Archives of Physiology and Biochemistry·Zienab Alrefaie, Hossam Awad
Apr 24, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Erfan TasdighiMahnoosh Foroughi
Jul 20, 2017·European Journal of Clinical Investigation·Ting-Wei LeeYi-Jen Chen
Jun 30, 2019·Cellular and Molecular Life Sciences : CMLS·Ting-Wei LeeTing-I Lee
Jan 11, 2017·Journal of Biomedical Science·Ting-Wei LeeYi-Jen Chen
Jan 7, 2021·International Journal of Molecular Sciences·Sara PanizoJorge B Cannata-Andía
Nov 12, 2020·International Journal of Molecular Sciences·Pao-Chia ChouShuen-Ei Chen
Jun 9, 2021·The Journal of Nutritional Biochemistry·Salma M Eraky, Nehal M Ramadan

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