Potential of xanthones from tropical fruit mangosteen as anti-cancer agents: caspase-dependent apoptosis induction in vitro and in mice

Applied Biochemistry and Biotechnology
Ramida WatanapokasinTakeshi Sano

Abstract

The pericarp of mangosteen (Garcinia mangostana L.) is rich in various xanthones that are known to possess unique biological activities. In this work, we characterized the anti-proliferative and cytotoxic activities of mangosteen xanthones both in vitro and in mice. In vitro analysis with a human colorectal adenocarcinoma cell line, COLO 205, showed that mangosteen xanthones not only inhibit the proliferation of target cells but also induce their death by apoptosis that involves the activation of the caspase cascade. In vivo analysis using a mouse subcutaneous tumor model with COLO 205 cells showed that, at relatively low doses, the growth of tumors was repressed upon intratumoral administration of mangosteen xanthones. When a higher dose of mangosteen xanthones was administered, the size of tumors was reduced gradually, and, in some mice, the disappearance of tumors was seen. Histopathological evaluation and biochemical analysis of tumors that received mangosteen xanthones indicate the induction of apoptosis in tumors, which resulted in the repression of their growth and the reduction of their sizes. These results demonstrate the potential of mangosteen xanthones to serve as anti-cancer agents for the chemotherapy of cancer.

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Citations

May 25, 2012·Journal of Natural Medicines·Nuttavut KosemPrimchanien Moongkarndi
Jul 23, 2013·BMC Complementary and Alternative Medicine·Weeranuch SeesomWasana Sukhumsirichart
May 7, 2011·World Journal of Gastroenterology : WJG·Ramida WatanapokasinSunit Suksamrarn
May 21, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Yan ZhaoShijie Wang
Jun 19, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jing J WangBarbara J S Sanderson
Feb 22, 2012·Research in Veterinary Science·Aungkana KrajarngRamida Watanapokasin
Jun 2, 2016·Critical Reviews in Food Science and Nutrition·Choon Yoong CheokGun Hean Chong
Nov 12, 2015·BioMed Research International·Mohd Fadzelly Abu BakarAzizul Isha
Mar 13, 2017·Chinese Journal of Natural Medicines·Ming-Hui WangJin-Xin Wang
Jun 29, 2017·Phytotherapy Research : PTR·Hourieh Tousian ShandizHossein Hosseinzadeh
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anuwatchakij KlamrakNatsajee Nualkaew
Mar 31, 2011·Journal of Agricultural and Food Chemistry·Aungkana KrajarngRamida Watanapokasin

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