PMID: 19099151Dec 23, 2008Paper

Potential pathogenic role of aggregative-adhering Corynebacterium diphtheriae of different clonal groups in endocarditis

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
R HirataA L Mattos-Guaraldi

Abstract

Invasive diseases caused by Corynebacterium diphtheriae have been described increasingly. Several reports indicate the destructive feature of endocarditis attributable to nontoxigenic strains. However, few reports have dealt with the pathogenicity of invasive strains. The present investigation demonstrates a phenotypic trait that may be used to identify potentially invasive strains. The study also draws attention to clinical and microbiological aspects observed in 5 cases of endocarditis due to C. diphtheriae that occurred outside Europe. Four cases occurred in female school-age children (7-14 years) treated at different hospitals in Rio de Janeiro, Brazil. All patients developed other complications including septicemia, renal failure and/or arthritis. Surgical treatment was performed on 2 patients for valve replacement. Lethality was observed in 40% of the cases. Microorganisms isolated from 5 blood samples and identified as C. diphtheriae subsp mitis (N = 4) and C. diphtheriae subsp gravis (N = 1) displayed an aggregative adherence pattern to HEp-2 cells and identical one-dimensional SDS-PAGE protein profiles. Aggregative-adhering invasive strains of C. diphtheriae showed 5 distinct RAPD profiles. Despite the clonal diversity...Continue Reading

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Citations

Jul 12, 2011·Veterinary Microbiology·A A S O DiasA L Mattos-Guaraldi
Jun 16, 2011·Proteomics·Ansgar PoetschAndreas Burkovski
Oct 16, 2015·Antonie van Leeuwenhoek·Louisy Sanches Dos SantosAna Luíza Mattos-Guaraldi
Dec 18, 2013·Microbiology·Renata Stavracakis PeixotoAna Luíza Mattos-Guaraldi
Apr 2, 2015·Antonie van Leeuwenhoek·Monica Cristina SouzaAna Luiza Mattos-Guaraldi
Feb 24, 2015·Epidemiology and Infection·L S SantosA L Mattos-Guaraldi
Jul 17, 2014·Journal of Infection and Public Health·Rosemarie Philippa FitzGeraldDona Nelun Perera
Jun 6, 2012·Memórias do Instituto Oswaldo Cruz·Monica Cristina de SouzaAna Luiza de Mattos Guaraldi
Sep 1, 2020·Current Protocols in Microbiology·Chungyu ChangHung Ton-That
Aug 5, 2020·The Journal of Antimicrobial Chemotherapy·Durdica V MarosevicAndreas Sing
Nov 5, 2019·BMJ Case Reports·Una Sutton-FitzpatrickCatherine Fleming
Dec 3, 2016·Journal of Medical Microbiology·Renata Stavracakis PeixotoAna Luíza Mattos-Guaraldi
Nov 30, 2011·Revista de saúde pública·Alexandre Alves de Souza de Oliveira DiasAna Luíza Mattos Guaraldi

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