Potential Prognostic Markers of Acute Kidney Injury in the Early Phase of Acute Pancreatitis

International Journal of Molecular Sciences
Justyna WajdaBeata Kuśnierz-Cabala

Abstract

Acute kidney injury (AKI) is a serious complication of acute pancreatitis (AP), which occurs in up to 70% of patients with severe AP and significantly increases the risk of mortality. At present, AKI is diagnosed based on dynamic increase in serum creatinine and decreased urine output; however, there is a need for earlier and more accurate biomarkers. The aim of the study was to review current evidence on the laboratory tests that were studied as the potential biomarkers of AKI in AP. We also briefly summarized the knowledge coming from the studies including sepsis or ICU patients since severe acute pancreatitis is associated with systemic inflammation and organ failure. Serum cystatin C and serum or urine NGAL have been shown to predict or diagnose AKI in AP; however, this evidence come from the single center studies of low number of patients. Other markers, such as urinary kidney injury molecule-1, cell cycle arrest biomarkers (tissue inhibitor metalloproteinase-2 and urine insulin-like growth factor-binding protein 7), interleukin-18, liver-type fatty acid-binding protein, or calprotectin have been studied in other populations suffering from systemic inflammatory states. In AP, the potential markers of AKI may be significant...Continue Reading

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Citations

Jul 28, 2020·International Journal of Molecular Sciences·Shaoshi WenTao Wang
Jan 2, 2020·International Journal of Molecular Sciences·Beáta RókaPéter Hamar
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Lin YiWen-Fu Tang
May 25, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aravind ThavamaniSenthilkumar Sankararaman

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