Potential protection of skin by acute UVA irradiation--from cellular to animal models

Progress in Biophysics and Molecular Biology
R M Tyrrell, V E Reeve

Abstract

The UVA (320-380 nm) component of sunlight has oxidizing properties which may be deleterious to skin cells and tissue but can also lead to the strong up-regulation of the heme-catabolizing enzyme, heme oxygenase-1. This enzyme has well-established antioxidant actions in cells as well as anti-inflammatory properties in mammals. There is also evidence from rodent models that this enzyme is responsible for the UVA-mediated protection against UVB-induced immunosuppression that occurs in skin. The relevance of these findings to acute and chronic effects of sunlight including skin carcinogenesis is currently under investigation as are the potential implications for sunlight protection in humans.

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S M Keyse, R M Tyrrell
Aug 1, 1987·Photochemistry and Photobiology·M J Connor, L A Wheeler
Jan 1, 1996·Nature Medicine·D WillisD A Willoughby
Feb 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R M Tyrrell
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·C PourzandR M Tyrrell
Jun 26, 1999·The Journal of Investigative Dermatology·V E ReeveN Nishimura
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·V E Reeve, R M Tyrrell
Mar 17, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L SkovO Baadsgaard
Jan 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jiying SunKazuhiko Igarashi
Apr 23, 2004·The Journal of Investigative Dermatology·Munif Allanson, Vivienne E Reeve
Mar 2, 2005·The Journal of Investigative Dermatology·Munif Allanson, Vivienne E Reeve
Mar 8, 2005·Mutation Research·Stephen E Ullrich

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Citations

Apr 19, 2007·Cancer Immunology, Immunotherapy : CII·Munif Allanson, Vivienne E Reeve
Apr 1, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Shelley GormanPrue H Hart
Apr 1, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Katie M DixonRebecca S Mason
May 8, 2015·Nutrients·Shelley GormanRichard Weller
Jun 19, 2009·The Journal of Investigative Dermatology·Ikuko NumataSetsuya Aiba
Mar 8, 2008·Journal of Photochemistry and Photobiology. B, Biology·Céline BottaMichel De Méo
Jan 26, 2007·Pigment Cell Research·Yoshinori MiyamuraVincent J Hearing
Mar 8, 2012·Journal of Cellular Biochemistry·Jongsung LeeDeokhoon Park
Sep 13, 2013·The British Journal of Dermatology·R RezzaniR J Reiter
Sep 11, 2014·Photochemistry and Photobiology·Muhammad Farrukh NisarJulia Li Zhong
Oct 21, 2014·Photochemistry and Photobiology·Jean CadetJean-Luc Ravanat
Jan 23, 2017·Free Radical Biology & Medicine·André Passaglia SchuchCamila Carrião Machado Garcia
Jan 30, 2019·Free Radical Research·Fangfang XueJulia Li Zhong
Mar 2, 2019·The British Journal of Dermatology·P H Hart
Oct 12, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Asma ArounCharareh Pourzand
Mar 1, 2012·Journal of Pharmacy & Bioallied Sciences·Vasim KhanK K Pillai
Feb 22, 2007·International Journal of Cancer. Journal International Du Cancer·Thomas WeihkopfAndreas Seidler
Jan 3, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jun-Lae ChoVivienne E Reeve
Nov 4, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jun-Lae ChoVivienne E Reeve
Jan 28, 2012·Bioscience Trends·Yuancai XiangJulia Li Zhong
Oct 5, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Vivienne E ReeveNicole Painter
Jan 31, 2021·Nature Reviews. Immunology·Nicole K CampbellAisling Dunne
Mar 7, 2021·Cancers·Luc RochetteCatherine Vergely
May 13, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Yuko IbukiTatsushi Toyooka

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