Potential protective immunogenicity of tetanus toxoid, diphtheria toxoid and Cross Reacting Material 197 (CRM197) when used as carrier proteins in glycoconjugates

Human Vaccines & Immunotherapeutics
Michael Bröker

Abstract

When tetanus toxoid (TT), diphtheria toxoid (DT) or Cross Reacting Material 197 (CRM197), a non-toxic diphtheria toxin mutant protein, are used as carrier proteins in glycoconjugate vaccines, these carriers induce a protein specific antibody response as measured by in vitro assays. Here, it was evaluated whether or not glycoconjugates based on TT, DT or CRM197 can induce a protective immune response as measured by potency tests according to the European Pharmacopoeia. It could be shown, that the conjugate carriers TT and DT can induce a protective immune response against a lethal challenge by toxins in animals, while glycoconjugates based on CRM197 failed to induce a protective immune response. Opportunities for new applications of glycoconjugates are discussed.

References

Dec 11, 2014·Expert Review of Vaccines·Marco Aurélio SáfadiUNKNOWN Global Meningococcal Initiative
Dec 17, 2014·Expert Opinion on Biological Therapy·Mairi Vella, David Pace

❮ Previous
Next ❯

Citations

Mar 5, 2016·Human Vaccines & Immunotherapeutics·Michael BrökerPaolo Costantino
Oct 16, 2016·Journal of Neuro-oncology·Amanda TivnanJochen H M Prehn
Jan 9, 2018·Journal of Immunoassay & Immunochemistry·Stefan Alexandru ArteneAnica Dricu
May 20, 2020·Infection and Drug Resistance·Clara Carreras-AbadKirsty Le Doare
Feb 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ariel M SlifkaMark K Slifka
Jan 19, 2019·PeerJ·Yao LeiYongguang Zhang
Jul 3, 2019·Vaccine·Anthony AlmudevarMichael Pichichero
Sep 23, 2021·Expert Review of Vaccines·Henderson ZhuAndrew J Pollard
Sep 25, 2021·Critical Reviews in Microbiology·Roghayeh MohammadzadehHadi Farsiani

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
ELISA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.