PMID: 3758144Jan 1, 1986Paper

Potential pulmonary uptake and clearance of morphine in postoperative patients

European Journal of Clinical Pharmacology
M P PerssonL K Paalzow

Abstract

The influence of lung uptake and lung clearance on the disposition of morphine was studied in surgical patients. In the postoperative period morphine was given intravenously by a two-rate infusion regimen. Under steady-state conditions samples of mixed central venous blood (pulmonary artery) and peripheral arterial blood (radial artery) were taken simultaneously and at the same time cardiac output was measured. The concentration differences between venous and arterial blood were used to calculate the extraction ratio of morphine across the lung. In all patients there was marked pulmonary uptake, but the concentration differences in most of them were small under steady-state conditions. The extraction ratio (mean +/- SD) across the lung was 0.06 +/- 0.10, implying insignificant lung clearance. However, in two patients, both with diabetes mellitus, there was a significant concentration gradient, indicating that the lung could contribute to the total body elimination of morphine. On the other hand, the total clearance was similar in diabetic and nondiabetic patients (1190 and 1150 ml/min, respectively), implying that pulmonary clearance would have no significant influence on the kinetics of morphine. A physiologically based pharma...Continue Reading

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Citations

Jan 1, 1988·Pharmacology & Therapeutics·A MelanderA McLean
Feb 1, 1988·British Journal of Clinical Pharmacology·M P PerssonL Paalzow
Nov 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G R Park

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