PMID: 2504925Jun 1, 1989Paper

Potential regulatory elements of nematode vitellogenin genes revealed by interspecies sequence comparison

Journal of Molecular Evolution
E Zucker-Aprison, T Blumenthal

Abstract

The nematode, Caenorhabditis elegans, has a six-member gene family encoding vitellogenins, the yolk protein precursors. These genes are expressed exclusively in the intestine of the adult hermaphrodite. Here we report the cloning of all five members of the homologous gene family from another Caenorhabditis species, Caenorhabditis briggsae. Nucleotide sequence analysis of these genes reveals they are about 85% identical to the C. elegans genes in the coding regions. Overall similarity is much reduced in noncoding and flanking regions. However, two repeated heptamers, previously identified in the upstream regions of the C. elegans genes, are largely conserved in both location and sequence in C. briggsae. Conservation of certain of these heptamers suggests that proteins bound at these positions may be especially important to promoter function and/or regulation. Comparative sequence analysis also suggests the possibility that the first 70 bases of the vitellogenin mRNAs can be folded into stable secondary structures. Almost all base differences between the two species occur in sequences predicted to be unpaired, suggesting that the ability to form intrastrand base pairs has been selected during Caenorhabditis evolution.

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Citations

Dec 1, 1991·Journal of Molecular Evolution·C J JaworskiJ Piatigorsky
Apr 1, 1992·Molecular and Biochemical Parasitology·C Ray, J H McKerrow
Feb 28, 2003·Developmental Biology·Thomas M BrodiganMichael Krause
Feb 15, 2000·Research in Microbiology·M S Gelfand
Oct 1, 1996·Parasitology·C J LilleyH J Atkinson
Oct 25, 1994·Nucleic Acids Research·P E Kuwabara, S Shah
Jun 27, 2013·WormBook : the Online Review of C. Elegans Biology·Valerie ReinkePeter Okkema
Dec 1, 1996·Current Opinion in Genetics & Development·T Blumenthal, J Spieth
Sep 26, 2019·Frontiers in Physiology·Marcos Francisco Perez, Ben Lehner
Feb 1, 1997·Molecular and Cellular Biology·D A ZorioT Blumenthal
Sep 2, 2010·Journal of Proteome Research·Holger HusiMalcolm Walkinshaw

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