Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage

Circulation
Hirofumi NikaidoToshio Tanaka

Abstract

Cerebral vasospasm can be defined as delayed-onset narrowing of the cerebral arteries that can occur after a spontaneous aneurysmal subarachnoid hemorrhage (SAH). Despite a large number of experimental and clinical investigations, the exact pathophysiology of vasospasm remains unknown. Using a fluorescence differential-display system, we have identified the gene encoding heat shock protein 72 (HSP72) as being highly upregulated by cerebral vasospasm. We therefore elucidated the role of the HSP72 gene in cerebral vasospasm in a rat experimental SAH model. By angiography, cerebral vasospasm was detected from day 1, with maximal narrowing detected on day 2. Intracisternal injection of antisense HSP72 oligodeoxynucleotide led to specific inhibition of HSP72 gene expression and significantly aggravated cerebral vasospasm on days 2 and 3 of the angiographic studies. Oral administration of geranylgeranylacetone (GGA), an antiulcer drug, enhanced HSP72 induction and reduced cerebral vasospasm. These results suggest HSP72 plays a novel role in antagonizing delayed cerebral vasospasm after SAH and that GGA provides protective effects against delayed cerebral vasospasm, at least partly via induction of HSP72.

References

Sep 1, 1991·Journal of Neurosurgery·J M FindlayM G Grace
Jan 1, 1995·British Journal of Neurosurgery·N W Dorsch
May 1, 1995·Pharmacology & Therapeutics·D A Cook
Jul 31, 1993·Lancet·P Harrison
Feb 25, 1996·Experimental Cell Research·A Samali, T G Cotter
Aug 14, 1996·Biochemical and Biophysical Research Communications·M J SlepianL Whitesell
Sep 1, 1997·Molecular and Cellular Biology·D D MosserB Massie
Aug 5, 1998·Journal of Molecular and Cellular Cardiology·K SuzukiH Matsuda
Oct 20, 1998·Annals of Neurology·M A YenariG K Steinberg
Nov 10, 1998·Clinical and Experimental Pharmacology & Physiology·C G Sobey, F M Faraci
Jul 7, 1999·The Journal of Clinical Investigation·H SuzukiT Tanaka
Apr 13, 2002·Japanese Journal of Pharmacology·Richard SercombePhilippe Gomis
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Cecil O BorelLaura Niklason
Jun 24, 2003·Journal of Molecular and Cellular Cardiology·Kunitoshi YamanakaTetsunori Saikawa

❮ Previous
Next ❯

Citations

Dec 15, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Matthew A NystoriakGeorge C Wellman
Jan 5, 2008·Neurological Research·Ralf Dirk Rothoerl, Florian Ringel
Aug 24, 2010·British Journal of Neurosurgery·Serge MarbacherNeil D Kitchen
Nov 22, 2011·World Neurosurgery·Robert G WhitmoreSherman C Stein
Sep 18, 2007·Journal of Neuroscience Methods·Takashi SugawaraJohn H Zhang
Aug 28, 2012·Journal of Neuroscience Methods·M A Muñoz-SánchezF Murillo-Cabezas
May 21, 2008·Journal of Pharmacological Sciences·Toshio TanakaYuhei Nishimura
Jun 3, 2006·Stroke; a Journal of Cerebral Circulation·Keiji KidoguchiKeiji Umetani
Jul 6, 2019·Journal of Cellular and Molecular Medicine·Anwen ShaoYongchuan Deng
Apr 18, 2008·American Journal of Physiology. Renal Physiology·Haiping MaoXueqing Yu
Jul 18, 2018·International Journal of Molecular Sciences·Shafqat Rasul ChaudhrySajjad Muhammad
Oct 6, 2005·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Toshio Tanaka
Sep 15, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Toshio TanakaHiroshi Iwao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.