Potential role of antibiotics in the treatment of asthma

Current Drug Targets. Inflammation and Allergy
Francesco BlasiL Allegra

Abstract

Although the role of antibiotic treatment in asthma is still disputed, clinical use of antimicrobials in this setting is more widespread than warranted on the basis of indications in the literature. Viral upper respiratory tract infections are known to be involved in asthma exacerbations. More recently, evidence of Mycoplasma pneumoniae and Chlamydia pneumoniae involvement in asthma attacks has been reported both in adult and paediatric populations. These pathogens are also involved in chronic asthma, and both in vitro and animal model studies indicate that atypical agents may play a role in the pathogenesis of the disease. Recent studies on asthma patients with evidence of atypical infection suggest that specific antimicrobial treatment (basically macrolides or fluoroquinolones) may confer additional advantages compared to standard therapy alone. Furthermore, a considerable amount of data has been gathered describing additional effects associated with macrolide treatment (reduced bronchial hyper-responsiveness, altered cytokine production, etc.). These non-antimicrobial effects have been defined as "anti-inflammatory activity". Should this information be confirmed, the use of macrolides in patients with asthma may be twofold: ...Continue Reading

Citations

Nov 23, 2011·European Journal of Clinical Pharmacology·P ZarogoulidisK Zarogoulidis
Oct 22, 2011·World Journal of Pediatrics : WJP·Xiao-Fang Wang, Jian-Guo Hong
Jul 11, 2006·The New England Journal of Medicine·Gaetano Caramori, Alberto Papi
Apr 18, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Lan Fang TangZhi Min Chen
Mar 14, 2007·International Journal of Antimicrobial Agents·Francesco Blasi, Sebastian L Johnston
Nov 18, 2005·Respiratory Medicine·Girolamo PelaiaSerafino A Marsico
May 17, 2007·Current Opinion in Pediatrics·Rebekah Mannix, Richard Bachur

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