PMID: 9421349Jan 8, 1998Paper

Potential role of bcl-2 as a suppressor of tumour angiogenesis in non-small-cell lung cancer

International Journal of Cancer. Journal International Du Cancer
M KoukourakisA L Harris

Abstract

It has been reported that genes regulating apoptosis may play a role in tumoral angiogenesis. This study examined the relationship between tumour vascularization, a measure of tumour angiogenesis, and bcl-2 and p53 expression in operable non-small-cell lung cancer (NSCLC). The relationship between bcl-2, p53 and tumour vascularization and epidermal-growth-factor-receptor(EGFR) and c-erbB-2 expression was also studied. Tissue sections from resected tumour specimens of 107 NSCLC patients were evaluated immunohistochemically for vascular grade and bcl-2, p53, EGFR and c-erbB-2 expression. bcl-2 expression was found in 20/107 (19%) cases and was associated with squamous-cell histology (p = 0.03). A strong inverse relationship was found between bcl-2 expression and vascular grade (p = 0.005). All c-erbB-2-positive cases were negative for bcl-2 expression (p = 0.01). Overall no association was found between c-erbB-2 expression and vascular grade. However, in bcl-2-negative cases positive c-erbB-2 expression correlated with low angiogenesis (p = 0.05). No relationship was found between p53 and EGFR expression and bcl-2, c-erbB-2 or vascular grade. The improved prognosis reported in bcl-2-positive NSCLC may be related to low tumour vas...Continue Reading

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Citations

Sep 29, 2004·Journal of Clinical Pathology·A E Greijer, E van der Wall
Jun 30, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Seong Hyun JeongSeung Soo Sheen
Sep 16, 2004·Seminars in Thoracic and Cardiovascular Surgery·Jonathan C Daniel, W Roy Smythe
Jan 24, 2007·Thoracic Surgery Clinics·Adam Yagui-BeltránDavid M Jablons
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Dec 23, 1998·Cancer Treatment Reviews·R DziadziuszkoJ Jassem
Aug 8, 2006·Cancer Treatment Reviews·Jill L O'DonnellDavid Bouchier-Hayes
Dec 6, 2005·The Journal of Surgical Research·Loucas GeorgiouEfthimios Sivridis
Oct 8, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Julian A CrastaElizabeth Vallikad
Mar 5, 2003·Pharmacological Reviews·Romano DanesiMario Del Tacca
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May 28, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Leos KrenJeffrey S Ross
Nov 30, 2016·Oncology Letters·Ulrich NitscheMert Erkan

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