Potential role of CCL27 and CCR10 expression in melanoma progression and immune escape

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Oriana SimonettiAnnamaria Offidani

Abstract

Aim of this study was to investigate using immunohistochemistry techniques the interrelation between T immunoreactive cells and the expression of CCR10 and its ligand CCL27 in 59 cutaneous melanocytic lesions. In malignant melanomas, T lymphocyte density was significantly decreased from thin melanomas to intermediate and thick ones (P<0.0005). CCR10 expression was found both in benign and malignant lesions and it was directly correlated with the Breslow depth (P=0.0298) and inversely with T lymphocyte density (P=0.0231). Moreover, cases with positive sentinel lymph node tended to have a higher CCR10 expression compared to cases with negative sentinel lymph node (P=0.0281). When CCR10 and CCL27 expression were evaluated together, CCR10-/CCL27-melanomas tended to have a higher mean density of CD3+ and CD8+ lymphocytes. Our results suggest that in human melanomas CCR10 and CCL27 may act to increase the ability of neoplastic cells to grow, invade tissue, disseminate to lymph nodes and to escape the host immune response.

References

Dec 20, 1989·Journal of the National Cancer Institute·W H ClarkA C Halpern
Nov 10, 1995·The Journal of Biological Chemistry·R M StrieterD Marriott
Jun 1, 1997·Immunology Today·T BoonB Van den Eynde
Jan 9, 1998·Baillière's Clinical Haematology·G J Graham
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·J MoralesA Zlotnik
Feb 5, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S LyleD E Elder
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B HomeyA Zlotnik
Sep 26, 2001·Archives of Pathology & Laboratory Medicine·A SlominskiM C Mihm
Feb 1, 2002·Nature Medicine·Bernhard HomeyAlbert Zlotnik
Jun 13, 2002·The Journal of Investigative Dermatology·Aimee S Payne, Lynn A Cornelius
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas GortzGerard J Graham
Oct 29, 2003·The Journal of Experimental Medicine·Takashi MurakamiSam T Hwang
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuelle ViguierLaurent Ferradini

❮ Previous
Next ❯

Citations

Sep 11, 2007·Cancer Metastasis Reviews·Seema SinghRakesh K Singh
Sep 25, 2007·Clinical & Experimental Metastasis·Adit Ben-Baruch
Jun 28, 2008·Pigment Cell & Melanoma Research·Hwa Jin LeeSuzie Chen
Feb 19, 2009·Pigment Cell & Melanoma Research·Ann RichmondYingjun Su
Jan 1, 2009·Immunotherapy·Trina J Stewart, Mark J Smyth
Apr 12, 2011·Cellular and Molecular Life Sciences : CMLS·Friedemann Kiefer, Arndt F Siekmann
Mar 7, 2007·Expert Review of Anticancer Therapy·W Andrew Yeudall, Hiroshi Miyazaki
Dec 18, 2010·Annals of Dermatology·Yoon-Jin LeeMoon-Kyun Cho
Dec 15, 2010·Pathology, Research and Practice·Hiromichi KaiShinichi Sato
Dec 17, 2009·Cytokine & Growth Factor Reviews·Alberto MantovaniRaffaella Bonecchi
Dec 6, 2008·Journal of the American Academy of Dermatology·Stephen Chu-Sung HuCheng-Che E Lan
Jun 18, 2010·The Journal of Investigative Dermatology·Bonnie E Gould Rothberg, David L Rimm
Nov 19, 2008·Seminars in Cancer Biology·Nicole Gross, Roland Meier
May 3, 2011·Actas dermo-sifiliográficas·C MonteagudoD Ramos
Jan 13, 2011·Experimental Cell Research·Dayanidhi RamanAnn Richmond
Apr 4, 2015·Journal of Immunoassay & Immunochemistry·Monica NeaguCaterina Longo
Dec 8, 2010·Experimental Cell Research·Paola AllavenaAlberto Mantovani
Jan 1, 2010·Cancers·William E DamskyMarcus Bosenberg
Aug 26, 2011·Nature Reviews. Immunology·Albert ZlotnikBernhard Homey
Oct 16, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nayoung LeeTobias Schatton
Nov 16, 2011·Melanoma Research·Travis E GrotzSvetomir N Markovic
Jul 13, 2007·International Journal of Immunopathology and Pharmacology·O SimonettiA Offidani
May 25, 2013·World Journal of Gastroenterology : WJG·Hiroshi MiyazakiW Andrew Yeudall
Nov 22, 2013·Oncotarget·Purvaba J SarvaiyaMaciej S Lesniak
Jun 30, 2019·Cancers·Monique K van der KooijEllen Kapiteijn
Nov 14, 2018·Frontiers in Immunology·Nicolas JacquelotLaurence Zitvogel
Jun 22, 2016·Cancer Research·Yangyang HuQiao Li
Feb 3, 2019·Cancer Research·Tara KarnezisSteven A Stacker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

Related Papers

The Journal of Experimental Medicine
Takashi MurakamiSam T Hwang
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Farin F AmersiDave S B Hoon
International Journal of Cancer. Journal International Du Cancer
Klaus GüntherReinhold Förster
Proceedings of the National Academy of Sciences of the United States of America
Andor PivarcsiB Homey
© 2022 Meta ULC. All rights reserved