Potential Role of Endonuclease Inhibition and Other Targets in the Treatment of Influenza.

Current Drug Targets
Doreen Szollosi, Ashley Bill

Abstract

Influenza is a single-stranded RNA virus that is highly contagious and infects millions of people in the U.S. annually. Due to complications, approximately 959,000 people were hospitalized and another 79,400 people died during the 2017-2018 flu season. While the best methods of prevention continue to be vaccination and hygiene, antiviral treatments may help reduce symptoms for those who are infected. Until recently, the only antiviral drugs in use have been the neuraminidase inhibitors: oseltamivir, zanamivir, and peramivir. We reviewed novel drug targets that can be used in the treatment of influenza, particularly in the case of neuraminidase inhibitor-resistant strains that may emerge. More recently, a drug with a new mechanism of action has been approved. Baloxavir marboxil inhibits the influenza cap-dependent endonuclease that is needed for the virus to initiate replication within the host cell. This endonuclease target is within the polymerase acid (PA) subunit of RNA polymerase. Since the RNA-dependent RNA polymerase consists of two other subunits, polymerase basic 1 and 2, RNA polymerase has several targets that prevent viral replication. Other targets still under investigation include viral kinases, endocytosis, and vir...Continue Reading

References

Apr 15, 1999·International Journal of Molecular Medicine·M KurokawaA Adachi
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Y FurutaK Shiraki
Dec 21, 2002·The Journal of Antimicrobial Chemotherapy·F Y AokiUNKNOWN IMPACT Study Group
Dec 4, 2003·Science·Richard J Webby, Robert G Webster
Apr 14, 2005·Journal of Virology·Othmar G EngelhardtErvin Fodor
Sep 30, 2005·The New England Journal of Medicine·Anne Moscona
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·Michael P MalakhovFang Fang
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Maki KisoYoshihiro Kawaoka
Jan 29, 2010·Journal of Clinical Microbiology·Barbara BiereBrunhilde Schweiger
Mar 10, 2010·Nature Biotechnology·Ji-Young Min, Kanta Subbarao
May 11, 2010·Biochimica Et Biophysica Acta·Rafal M Pielak, James J Chou
Jun 11, 2010·Journal of Virology·Yung-Chia ChenMichael M C Lai
May 4, 2011·Journal of the American Chemical Society·Hadas LeonovIsaiah T Arkin
Jul 9, 2011·Science·Damian C EkiertJaap Goudsmit
Dec 22, 2011·The Lancet Infectious Diseases·Aeron C HurtUNKNOWN WHO Consultation on Pandemic Influenza A (H1N1) 2009 Virus Resistance to Antivirals
Apr 27, 2012·Journal of Clinical Microbiology·Rachel R HigginsJonathan B Gubbay
Oct 10, 2012·The Journal of Infectious Diseases·Ronald B MossRoy T Steigbigel
Mar 19, 2013·FEBS Letters·Wenjie Zheng, Yizhi Jane Tao
Oct 3, 2013·Antiviral Research·Yousuke FurutaDale L Barnard
May 24, 2014·The Lancet Infectious Diseases·Jason HaffizullaUNKNOWN US Nitazoxanide Influenza Clinical Study Group
Jun 24, 2014·Nature Reviews. Molecular Cell Biology·Sihem ZitouniMónica Bettencourt-Dias
Jul 16, 2014·Journal of Medicinal Chemistry·Michael P ClarkPaul S Charifson
Aug 12, 2014·Antiviral Research·Jean-François Rossignol
Nov 29, 2014·Future Virology·Thomas M Stubbs, Aartjan Jw Te Velthuis
Dec 30, 2014·Disaster Medicine and Public Health Preparedness·Takashi NagataMasami Ishii
Mar 31, 2015·Indian Journal of Pharmacology·Yogendra Kumar GuptaPrafull Mohan
Aug 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kannan TharakaramanZachary Shriver
Jan 21, 2016·Antimicrobial Agents and Chemotherapy·Tatiana BaranovichElena A Govorkova
Dec 9, 2016·Pathogens·Patrick R Saunders-Hastings, Daniel Krewski
Feb 2, 2017·Influenza and Other Respiratory Viruses·Paulina KoszalkaAeron C Hurt
Apr 27, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ahmed DiabDavid Durantel
May 2, 2017·Infection and Drug Resistance·Mazhar HussainMatloob Husain
May 24, 2017·European Journal of Pharmacology·Simonides I van de WakkerRonald S Oosting
Aug 5, 2017·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Yousuke FurutaTakaaki Nakamura

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