Potential Role of Gut Microbiota in ALS Pathogenesis and Possible Novel Therapeutic Strategies

Journal of Clinical Gastroenterology
Letizia MazziniGiovanni Mogna

Abstract

Recent preclinical studies suggest that dysfunction of gastrointestinal tract may play a role in amyotrophic lateral sclerosis (ALS) pathogenesis through a modification of the gut microbiota brain axis. Our study is the first focused on microbiota analysis in ALS patients. Our aim was to study the main human gut microbial groups and the overall microbial diversity in ALS and healthy subjects. Moreover we have examined the influence of a treatment with a specific bacteriotherapy composed of Lactobacillus strains (Lactobacillus fermentum, Lactobacillus delbrueckii, Lactobacillus plantarum, Lactobacillus salivarius) acting on the gastrointestinal barrier. We enrolled 50 ALS patients and 50 healthy controls, matched for sex, age, and origin. Fecal samples were used for total genomic DNA extraction. Enterobacteria, Bifidobacterium spp., Lactobacillus spp., Clostridium sensu stricto, Escherichia coli and yeast were quantified using quantitative polymerase chain reaction approach. Denaturing gradient gel electrophoresis analyses were performed to investigate total eubacteria and yeasts populations. Patients were randomized to double-blind treatment either with microorganisms or placebo for 6 months and monitored for clinical progressi...Continue Reading

Associated Clinical Trials

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Citations

Dec 18, 2018·Environmental Microbiology·Nina RadisavljevicBarton Brett Finlay
Oct 11, 2019·Disease Models & Mechanisms·Claudia Figueroa-RomeroEva L Feldman
Jun 4, 2020·Molecular Neurodegeneration·Rajka Maria LiscicEmanuele Buratti
Jun 11, 2020·International Journal of Molecular Sciences·Bruno TiloccaViviana Greco
Dec 25, 2019·The International Journal of Neuroscience·Astrid C ErberEva S Schernhammer
Jul 10, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Shyuan T NgoFrederik J Steyn
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Jun 13, 2020·Frontiers in Neuroscience·B KuraszkiewiczM de Carvalho
Jan 19, 2020·Journal of Neuroinflammation·Sibo ZhuXingdong Chen
Jul 3, 2020·Frontiers in Neuroscience·Zhouyang LiuChuansheng Zhao
Apr 6, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Vicki S HertzbergJonathan D Glass
Jun 9, 2021·Neural Regeneration Research·Cheng LiuFang Zhou
Aug 7, 2021·Metabolic Brain Disease·Ankit UniyalVinod Tiwari

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Methods Mentioned

BETA
electrophoresis
PCR

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