Potential role of interferons in treating COVID-19 patients.

International Immunopharmacology
Mohadeseh Haji AbdolvahabLeila Farahmand

Abstract

The recently public health crises in the world is emerged by spreading the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also named COVID-19. The virus is originated in bats and transported to humans via undefined intermediate animals. This virus can produce from weak to severe respiratory diseases including acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), pneumonia and even death in patients. The COVID-19 disease is distributed by inhalation via contaminated droplets or contact with infected environment. The incubation time is from 2 to 14 day and the symptoms are typically fever, sore throat, cough, malaise, fatigue, breathlessness among others. It needs to be considered that many infected people are asymptomatic. Developing various immunological and virological methods to diagnose this disease is supported by several laboratories. Treatment is principally supportive; however, there are several agents that are using in treating of COVID-19 patients. Interferons (IFNs) have shown to be crucial in fighting with COVID-19 disease and can be a suitable candidate in treatment of these patients. Combination therapy can be more effective than monotherapy to cure this disease. Prev...Continue Reading

References

Aug 1, 2000·Virology·L G Guidotti, F V Chisari
Aug 17, 2000·The Journal of Infectious Diseases·S N Han, S N Meydani
Apr 28, 2001·Cytokine & Growth Factor Reviews·D E Levy, A García-Sastre
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
May 16, 2003·Nature·Ron A M FouchierAlbert D M E Osterhaus
Jul 29, 2003·Investigative Ophthalmology & Visual Science·John J HooksBarbara Detrick
Aug 2, 2003·Lancet·J CinatlH W Doerr
Dec 25, 2003·JAMA : the Journal of the American Medical Association·Mona R LoutfyEleanor N Fish
Mar 20, 2004·Emerging Infectious Diseases·Lisa E HensleyThomas W Geisbert
Jun 18, 2004·Emerging Infectious Diseases·Emily L C TanLawrence W Stanton
Dec 21, 2004·Biochemical and Biophysical Research Communications·Birgit MorgensternJindrich Cinatl
Jan 20, 2005·American Journal of Respiratory and Critical Care Medicine·Yong JiangPeng Deng
Aug 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Graham SimmonsPaul Bates
Aug 23, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Nelson LeeDavid S Hui
Aug 1, 2006·Advances in Virus Research·Paul S Masters
Sep 14, 2006·PLoS Medicine·Lauren J StockmanPaul Garner
Apr 27, 2007·Journal of Virology·Jessica K Roth-CrossSusan R Weiss
May 2, 2008·Experimental Physiology·Yumiko ImaiJosef M Penninger
Mar 10, 2009·Cytokine & Growth Factor Reviews·Alfons Billiau, Patrick Matthys
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher R CroweJay K Kolls
Nov 4, 2009·Future Virology·Anna de LangBart L Haagmans
Oct 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Grigory RyzhakovIrina Udalova
Aug 1, 2010·Viruses·Patrick C Y WooKwok-Yung Yuen
May 11, 2012·Current Opinion in Virology·Allison L Totura, Ralph S Baric
Nov 13, 2012·American Journal of Respiratory and Critical Care Medicine·Akihiko IchikawaYumiko Imai

❮ Previous
Next ❯

Citations

Jun 1, 2021·Frontiers in Immunology·Rafaela Pires da SilvaAna Paula Duarte de Souza
May 18, 2021·Expert Review of Vaccines·Burcu Temizoz, Ken J Ishii
May 22, 2021·Frontiers in Pharmacology·Xinlei Li, Tao Peng
May 25, 2021·Frontiers in Medicine·Mirjam KienerMarianna Kruithof-de Julio
Jun 12, 2021·Journal of Clinical Immunology·Lina M Castano-JaramilloSaul O Lugo Reyes
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad Amin Khazeei TabariRoja Rahimi
Jul 10, 2021·Cytokine·Nataša Todorović-Raković, Jonathan R Whitfield
Aug 7, 2021·Pharmaceuticals·Jean Jacques Vanden Eynde
Aug 28, 2021·The Journal of Microbiology·Sandrine M SohHye-Ra Lee
Nov 19, 2021·Expert Review of Respiratory Medicine·Elena CojocaruRuxandra Rajnoveanu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.