Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain

Neural Plasticity
Han-Chung LeeKing-Hwa Ling

Abstract

Trisomy of human chromosome 21 in Down syndrome (DS) leads to several phenotypes, such as mild-to-severe intellectual disability, hypotonia, and craniofacial dysmorphisms. These are fundamental hallmarks of the disorder that affect the quality of life of most individuals with DS. Proper brain development involves meticulous regulation of various signaling pathways, and dysregulation may result in abnormal neurodevelopment. DS brain is characterized by an increased number of astrocytes with reduced number of neurons. In mouse models for DS, the pool of neural progenitor cells commits to glia rather than neuronal cell fate in the DS brain. However, the mechanism(s) and consequences of this slight neurogenic-to-gliogenic shift in DS brain are still poorly understood. To date, Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling has been proposed to be crucial in various developmental pathways, especially in promoting astrogliogenesis. Since both human and mouse models of DS brain exhibit less neurons and a higher percentage of cells with astrocytic phenotypes, understanding the role of JAK-STAT signaling in DS brain development will provide novel insight into its role in the pathogenesis of DS brain a...Continue Reading

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Jul 30, 2016·ELife·Kelly D SullivanJoaquín M Espinosa
Jul 27, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erin D LucasBeth A Jirón Tamburini
Dec 19, 2019·Stem Cells and Development·Masoumeh Zarei-KheirabadiHossein Baharvand
Aug 12, 2017·Frontiers in Cellular Neuroscience·Franz OswaldHolger Herlyn
Dec 11, 2019·Cells·Laura ReichePeter Göttle
Sep 1, 2020·Developmental Neurobiology·Patrick S CreisherLauren A O'Donnell
Feb 23, 2017·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Weili ShiBingtao Hao

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Methods Mentioned

BETA
chemical modification

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