PMID: 8461523Mar 1, 1993Paper

Potential role of neutrophil anti-adhesion therapy in myocardial stunning, myocardial infarction, and organ dysfunction after cardiopulmonary bypass

Journal of Cardiac Surgery
E D Verrier, I Shen

Abstract

When activated neutrophils are recruited and bind to endothelial tissues, they release leukotrienes, proteolytic enzymes, and free radicals. The latter has been implicated in myocardial stunning following periods of ischemia and reperfusion, as may occur following cardiopulmonary bypass (CPB). The neutrophil surface complex CD11/CD18 promotes the neutrophil-endothelial adhesion process. Monoclonal antibodies have been developed that can block neutrophil adhesion to the endothelium by preventing CD11/CD18 binding to adhesion molecules (ICAM-1 or ELAM-1) located on endothelial cells. We used monoclonal IgG antibody 60.3 to block neutrophil adherence and thereby potentially reduce myocardial stunning. Pretreatment of rabbits subjected to myocardial ischemia/reperfusion with either monoclonal 60.3 or saline resulted in only a small increase in the rate of recovery of preload recruitable stroke work index during reperfusion. More severe occlusion may have been needed to see significant results. We also evaluated the effects of anti-neutrophil therapy in animal models of CPB. Rhesus monkeys were subjected to deep hypothermia and CPB, followed by 24 hours of fluid resuscitation. Animals receiving monoclonal 60.3 (N = 3) showed less we...Continue Reading

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Citations

Sep 1, 1996·The Annals of Thoracic Surgery·E D Verrier, E M Boyle
Jan 26, 2000·International Journal of Cardiology·R SharmaS D Anker
Jul 4, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anthony C Chang
Jan 3, 2001·Journal of Molecular and Cellular Cardiology·Z Q ZhaoJ Vinten-Johansen
May 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·S A BuchananC G Tribble
Apr 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·J BoldtG Hempelmann
Apr 4, 1998·The Annals of Thoracic Surgery·J BoldtG Hempelmann
Oct 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·M K IltonJ Hung
Nov 24, 2006·Anesthesia and Analgesia·Michael E Jessen
Jan 1, 1995·Scandinavian Journal of Thoracic and Cardiovascular Surgery·J StarkopfJ Samarütel
Sep 5, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·J P ShannonR S Larson
Aug 5, 2003·The Journal of Peptide Research : Official Journal of the American Peptide Society·L O SillerudR S Larson

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