Potential role of platelets in COVID-19: Implications for thrombosis.

Research and Practice in Thrombosis and Haemostasis
Milka Koupenova

Abstract

For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019.

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Citations

Jul 14, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel MackmanNigel S Key
Sep 4, 2020·Seminars in Thrombosis and Hemostasis·Iván Parra-Izquierdo, Joseph E Aslan
Nov 6, 2020·Circulation Research·Milka Koupenova, Jane E Freedman
Oct 30, 2020·Journal of Thrombosis and Haemostasis : JTH·Robert A CampbellMatthew T Rondina
Feb 5, 2021·Research and Practice in Thrombosis and Haemostasis·Oonagh Shannon
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May 6, 2021·International Journal of Molecular Sciences·Olga ShevchukAlbert Sickmann
May 23, 2021·Journal of Thrombosis and Thrombolysis·Paul A GurbelRobert F Storey
Jul 27, 2021·Future Virology·Marzieh Saei Ghare NazFahimeh Ramezani Tehrani
Jul 24, 2021·Circulation Research·Milka KoupenovaJane E Freedman

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