Potential role of punicalagin against oxidative stress induced testicular damage

Asian Journal of Andrology
Faiza RaoFei Sun

Abstract

Punicalagin is isolated from pomegranate and widely used for the treatment of different diseases in Chinese traditional medicine. This study aimed to evaluate the effect of Punicalagin (purity ≥98%) on oxidative stress induced testicular damage and its effect on fertility. We detected the antioxidant potential of punicalagin in lipopolysaccharide (LPS) induced oxidative stress damage in testes, also tried to uncover the boosting fertility effect of Punicalagin (PU) against oxidative stress-induced infertility. Results demonstrated that 9 mg kg-1 for 7 days treatment significantly decreases LPS induced oxidative damage in testes and nitric oxide production. The administration of oxidative stress resulted in a significant reduction in testes antioxidants GSH, T-SOD, and CAT raised LPO, but treatment with punicalagin for 7 days increased antioxidant defense GSH, T-SOD, and CAT by the end of the experiment and reduced LPO level as well. PU also significantly activates Nrf2, which is involved in regulation of antioxidant defense systems. Hence, the present research categorically elucidates the protective effect of punicalagin against LPS induced oxidative stress induced perturbation in the process of spermatogenesis and significantl...Continue Reading

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Citations

Jun 17, 2016·Environmental Toxicology and Pharmacology·Amr A FouadWalid N Al-Melhim
Aug 17, 2016·International Journal of Molecular Sciences·Faiza RaoFei Sun
Aug 23, 2016·Toxicology and Applied Pharmacology·Cristiene Costa CarneiroLee Chen-Chen
Jan 14, 2017·The American Journal of Chinese Medicine·Mingge DingXiaoming Wang

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Methods Mentioned

BETA
PCR
Assay
electrophoresis

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