Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity.

European Journal of Human Genetics : EJHG
Virginia BoccardiM Barbieri

Abstract

Variants in transcription factor 7-like 2 (266096218TCF7L2266096218USuser266096218Gene names have been italicized per house style. Please check and confirm whether there are other instances that need to be italicized or instances where italics have been inappropriately applied.) gene have been found strongly associated with an increased risk of type 2 diabetes, as well as with an impairment of glucagon-like peptide-1 (GLP-1) signalling chain. In rats, stimulation of central GLP-1 receptors increases heart rate and activates autonomic regulatory neurons. We aimed to evaluate the potential role of TCF7L2 gene polymorphisms on sympathovagal response in relation to changes in plasma insulin and/or GLP-1 concentration after glucose ingestion. Genotyping was performed for rs12255372 and rs7903146 TCF7L2 gene variants in 250 non-related healthy volunteers (mean age 27±3 years). Consistent with previous reports, both single-nucleotide polymorphisms were in strong linkage disequilibrium (D'=0.87, r(2)=0.76). A subset of 167 patients underwent an oral glucose tolerance test while a continuous recording of heart rate variability was performed. At baseline, no differences in fasting plasma insulin, in GLP-1 levels and in LF/HF (low frequen...Continue Reading

References

Aug 1, 1991·Circulation·A MallianiS Cerutti
Sep 1, 1991·Circulation·A Fontbonne
Jun 1, 1991·The Journal of Clinical Investigation·E A AndersonA L Mark
Jun 25, 1999·Metabolism: Clinical and Experimental·G PaolissoM Varricchio
Jun 5, 2003·Journal of Hypertension·Ming YuRichard J Roman
Jan 30, 2004·Diabetes·Douglas R Seals, Christopher Bell
Sep 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·Thomas NyströmAke Sjöholm
Oct 13, 2004·Clinical Science·Daniela Manzella, Giuseppe Paolisso
Jan 15, 2005·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Robert E KleigerJ Thomas Bigger
Mar 1, 2005·Diabetes Care·Emily B SchroederUNKNOWN Atherosclerosis Risk in Communities (ARIC) study
Jan 18, 2006·Nature Genetics·Struan F A GrantKari Stefansson
Jul 21, 2006·The New England Journal of Medicine·Jose C FlorezUNKNOWN Diabetes Prevention Program Research Group
Apr 7, 2007·Journal of Hypertension·Giuseppe ManciaPeter A Van Zwieten
Jul 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adil E BharuchaPhillip A Low
Jul 5, 2008·Molecular Endocrinology·Tianru Jin, Ling Liu

❮ Previous
Next ❯

Citations

Jul 15, 2015·Annals of Human Genetics·Dhanasekaran BodhiniVenkatesan Radha
May 20, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kristy L JacksonGeoffrey A Head
Oct 7, 2021·Journal of Cellular Physiology·Laura Del Bosque-PlataClaudia Gragnoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.