Potential role of the IL-33/ST2 axis in celiac disease

Cellular & Molecular Immunology
M A López-CasadoM I Torres

Abstract

The IL-33/ST2 axis has been implicated in the pathogenesis of several tissue-specific autoimmune diseases. Celiac disease (CD) is the only autoimmune disease in which both the major genetic factors (HLA-DQ2/DQ8) and etiologic ones (dietary gluten) for susceptibility are known. We have measured serum levels and determined intestinal tissue expression of IL-33 and its receptor soluble ST2 in patients with CD to investigate their association with disease activity. Serum and tissue levels of both IL-33 and sST2 were significantly higher in patients with CD compared with those in control patients without CD. We show that toxic peptides extracted from barley and wheat gliadin significantly stimulate the production of IL-33 and ST2 in cultured peripheral blood mononuclear cell from celiac patients, strongly implicating the IL-33/ST2 axis in the pathogenesis of CD. The higher levels of IL-33 and its receptor ST2 in tissue and serum reflect an active inflammatory state and may represent a potential biomarker for disease activity. A better understanding of IL-33/ST2 release, mode of action, and regulation will be crucial to develop therapeutics that target the IL-33/ST2 pathway to treat CD.Cellular & Molecular Immunology advance online p...Continue Reading

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Citations

Mar 11, 2020·International Journal of Molecular Sciences·Weronika GonciarzMagdalena Chmiela
Aug 22, 2017·Frontiers in Microbiology·Aaron LernerTorsten Matthias
Jun 28, 2019·Cellular & Molecular Immunology·Candelaria Ponce de LeónMaría Isabel Torres
Sep 22, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Laura Rodríguez-MartínSantiago Vivas
May 10, 2017·Frontiers in Immunology·Brad Griesenauer, Sophie Paczesny
Mar 16, 2021·Frontiers in Immunology·Javier Sanchez-SolaresCristina Gomez-Casado
Jul 6, 2021·Frontiers in Immunology·Candelaria Ponce de LeónMaría Isabel Torres
Jul 25, 2021·International Journal of Molecular Sciences·Federico PerezFernando Gabriel Chirdo

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