Potential role of the intestinal microbiota of the mother in neonatal immune education

The Proceedings of the Nutrition Society
Anne Donnet-HughesEduardo J Schiffrin

Abstract

Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns.

References

Dec 1, 1978·The Journal of Pediatrics·P C Ho, J W Lawton
Apr 1, 1979·The Journal of Applied Bacteriology·P A WestO M Murphy
Nov 1, 1977·The Journal of Experimental Medicine·M E RouxM E Lamm
Jan 1, 1992·World Review of Nutrition and Dietetics·P J MoughanM Pedraza
Jun 1, 1988·Archives of Disease in Childhood·P KiteP Congdon
Nov 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·E S Buescher, S M McIlheran
Oct 1, 1993·American Journal of Infection Control·A E el-MohandesB J Jackson
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·P G FalkJ I Gordon
Apr 28, 2001·Journal of Clinical Microbiology·S NikkariD A Relman
Nov 22, 2001·American Journal of Obstetrics and Gynecology·N NaccashaR Romero
Feb 28, 2002·Annual Review of Immunology·Lars E TheillJosef M Penninger
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eilidh WilliamsonJoanne L Viney
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Markus NaglManfred P Dierich
Nov 28, 2002·Journal of Clinical Microbiology·Richard W McLaughlinEddie C S Chan
Jun 19, 2003·The American Journal of Clinical Nutrition·Bo Lönnerdal
Sep 4, 2003·The Journal of Clinical Investigation·Holm H Uhlig, Fiona Powrie
Dec 6, 2003·The Journal of Pediatrics·Rocío MartínJuan M Rodríguez
Mar 3, 2007·Pediatrics·Pablo F PerezAnne Donnet-Hughes
Oct 1, 2004·FEMS Microbiology Ecology·Irène ManginJoël Doré
Sep 1, 1977·Journal of Food Protection·A Gavin, K Ostovar

❮ Previous
Next ❯

Citations

Nov 18, 2011·Clinical Reviews in Allergy & Immunology·Graham A W Rook
Mar 22, 2013·Mucosal Immunology·M Fukata, M Arditi
May 28, 2013·BMC Microbiology·Tonya L WardIllimar Altosaar
Jun 6, 2013·Clinical & Developmental Immunology·Emilie Tourneur, Cecilia Chassin
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tina M HerfelJack Odle
Jun 25, 2014·Trends in Molecular Medicine·Yuliya E BorreJohn F Cryan
Jan 10, 2012·Annual Review of Food Science and Technology·Petra A M J ScholtensJan Knol
Mar 13, 2014·Applied and Environmental Microbiology·Camilla UrbaniakGregor Reid
Feb 13, 2016·Immunological Reviews·Duncan B SutherlandSidonia Fagarasan
Jan 26, 2016·American Journal of Physical Anthropology·Katherine R Amato
Jan 6, 2016·Nature Reviews. Endocrinology·Mikael Knip, Heli Siljander
Feb 8, 2016·Clinical Therapeutics·Timothy G ElginSteven J McElroy
Oct 23, 2012·The Journal of Allergy and Clinical Immunology·Samuli RautavaErika Isolauri
Aug 6, 2011·European Journal of Pharmacology·Per Brandtzaeg
Nov 2, 2015·Biochimica Et Biophysica Acta·Benjamin Y KleinMartha G Welch
Sep 12, 2015·Journal of Developmental Origins of Health and Disease·M J GosalbesM P Francino
Aug 12, 2014·Journal of Veterinary Internal Medicine·B C CredilleD J Hurley
Jan 22, 2015·Clinical and Experimental Immunology·M-C GaudreauC Vasu
Oct 3, 2014·Letters in Applied Microbiology·T M Wassenaar, P Panigrahi
Mar 22, 2014·Critical Reviews in Microbiology·Caroline A KerrGarry N Hannan
May 3, 2015·The Journal of Infection·Anu Goenka, Tobias R Kollmann
Dec 29, 2012·Beneficial Microbes·P V JeurinkR Martín
Jun 30, 2012·Gut Microbes·Maria Carmen ColladoGaspar Pérez-Martínez
Jan 29, 2014·Current Opinion in Biotechnology·Christophe ChassardChristophe Lacroix
Mar 24, 2015·Frontiers in Pediatrics·Emily C Gritz, Vineet Bhandari
Sep 17, 2013·The Journal of Allergy and Clinical Immunology·Randi J BertelsenStephanie J London
Oct 28, 2014·Frontiers in Pediatrics·Peris Mumbi MunyakaJean-Eric Ghia
Jul 16, 2016·International Journal of Pediatrics·Joyce Gomes de MoraesGiselia Alves Pontes da Silva
Sep 27, 2016·Frontiers in Pediatrics·William B Miller
Sep 20, 2016·The Journal of Physiology·Timothy G Dinan, John F Cryan
Apr 9, 2017·Biochemical and Biophysical Research Communications·Benjamin Y KleinM Anwar
Jan 24, 2012·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Virginia MartínEsther Jiménez
Mar 24, 2018·PloS One·Åsa VilsonHelene Hansson-Hamlin
May 25, 2016·Molecular BioSystems·M F AddisP Moroni

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Journal of Human Lactation : Official Journal of International Lactation Consultant Association
Virginia MartínE Jiménez
© 2021 Meta ULC. All rights reserved