Potential role of urinary angiotensinogen in predicting antiproteinuric effects of angiotensin receptor blocker in non-diabetic chronic kidney disease patients: a preliminary report

Postgraduate Medical Journal
Hye Ryoun JangYoon-Goo Kim

Abstract

Many chronic kidney disease (CKD) patients have persistent overt proteinuria despite angiotensin receptor blocker (ARB) treatment. This study investigated whether the initial difference in intrarenal renin-angiotensin system activity measured with urinary angiotensinogen would affect the antiproteinuric effects of ARB. Between September 2005 and September 2008, in 50 non-diabetic proteinuric CKD patients not taking renin-angiotensin system inhibitors, the urinary protein/creatinine ratio (P/Cr), angiotensinogen/creatinine ratio (AGT/Cr), plasma renin and aldosterone were measured before starting valsartan, and were followed for 18 months. Patients were divided into three groups according to their initial urinary AGT/Cr. The urinary P/Cr was lower in the low angiotensinogen group, but similar in the high and extremely high angiotensinogen groups (1.3±0.38 vs 2.0±0.92 vs 2.2±0.78). In all groups, the urinary P/Cr was decreased most for the first 6 months. The urinary P/Cr reduction at 6 months was greatest in the high angiotensinogen group (-24.2% vs -46.2% vs -16.4%). The urinary AGT/Cr was decreased most in the high angiotensinogen group. Renal functional deterioration was attenuated in the high angiotensinogen group compared w...Continue Reading

Citations

Aug 25, 2012·Pflügers Archiv : European journal of physiology·Hiroyuki Kobori, Maki Urushihara
Jun 15, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Hye Ryoun JangYoon-Goo Kim
Sep 29, 2015·Journal of Diabetes and Its Complications·Maryam AfkarianRajnish Mehrotra
May 6, 2014·Physiological Reports·Maryam AfkarianIan H de Boer

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