Potential Roles for G-Quadruplexes in Mitochondria

Current Medicinal Chemistry
Micol FalabellaBrett A Kaufman

Abstract

Some DNA or RNA sequences rich in guanine (G) nucleotides can adopt noncanonical conformations known as G-quadruplexes (G4). In the nuclear genome, G4 motifs have been associated with genome instability and gene expression defects, but they are increasingly recognized to be regulatory structures. Recent studies have revealed that G4 structures can form in the mitochondrial genome (mtDNA) and potential G4 forming sequences are associated with the origin of mtDNA deletions. However, little is known about the regulatory role of G4 structures in mitochondria. In this short review, we will explore the potential for G4 structures to regulate mitochondrial function, based on evidence from the nucleus.

References

Jan 1, 1992·International Review of Cytology·D A Clayton
Apr 9, 1981·Nature·S AndersonI G Young
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M Yakes, B Van Houten
Jan 1, 1997·Annual Review of Biochemistry·G S Shadel, D A Clayton
Aug 27, 1998·Molecular Biology and Evolution·A ReyesC Saccone
Dec 24, 1998·Nucleic Acids Research·H HanM Salazar
May 9, 2000·Biochemical and Biophysical Research Communications·T OhnoD Kang
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·J F RiouJ L Mergny
Aug 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Adam Siddiqui-JainLaurence H Hurley
Jul 15, 2004·Journal of the American Chemical Society·Anh Tuân PhanDinshaw J Patel
May 26, 2005·Nucleic Acids Research·Alan K ToddStephen Neidle
May 26, 2005·Nucleic Acids Research·Julian L Huppert, Shankar Balasubramanian
Jul 28, 2005·Journal of the American Chemical Society·Sarah RankinStephen Neidle
Mar 3, 2006·The EMBO Journal·Liana OganesianMichael B Jarstfer
Apr 20, 2006·Journal of the American Chemical Society·Thomas S DexheimerLaurence H Hurley
Apr 20, 2006·Journal of the American Chemical Society·Pascale HazelStephen Neidle
Jul 28, 2006·American Journal of Physiology. Cell Physiology·Allen KaasikVladimir Veksler
Aug 18, 2006·Nucleic Acids Research·Johanna Eddy, Nancy Maizels
Aug 29, 2006·Nucleic Acids Research·Jean-Baptiste Boulé, Virginia A Zakian
Oct 3, 2006·Nucleic Acids Research·Sarah BurgeStephen Neidle
Nov 30, 2006·Molecular and Cellular Biology·Bryan E SnowLea Harrington
Dec 16, 2006·Nucleic Acids Research·Julian L Huppert, Shankar Balasubramanian
Dec 21, 2006·Cancer Research·Haiyan QiLeroy F Liu
Sep 11, 2007·Biological & Pharmaceutical Bulletin·Kazunobu FutamiYasuhiro Furuichi
Aug 23, 2008·Nucleic Acids Research·Andrew N LaneJohn O Trent
Jul 10, 2009·Molecular BioSystems·Kangkan HalderShantanu Chowdhury
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Paulina H WanrooijClaes M Gustafsson
Oct 29, 2010·Molecular Biology of the Cell·Amy B EmermanRamanujan S Hegde
Jul 5, 2011·Nature Structural & Molecular Biology·Subhajyoti De, Franziska Michor

❮ Previous
Next ❯

Citations

Feb 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antara SenguptaShantanu Chowdhury
Oct 24, 2018·International Journal of Molecular Sciences·Wei-Chung Tsao, Kristin A Eckert
Oct 7, 2020·Nucleic Acids Research·Gabriele A Fontana, Hailey L Gahlon
Nov 13, 2020·Critical Reviews in Biochemistry and Molecular Biology·Stephanie TirmanAlessandro Vindigni
Nov 1, 2020·The Journal of Biological Chemistry·Urmimala BasuSmita S Patel
Jan 21, 2021·Nucleic Acids Research·Robert W HarknessAnthony K Mittermaier
Jan 18, 2021·The Journal of Biological Chemistry·Urmimala BasuSmita S Patel
May 22, 2021·Antioxidants & Redox Signaling·Gustavo CarvalhoPaulina H Wanrooij
Jun 2, 2020·Biochemistry·Maroof Khan ZafarAlicia K Byrd
Oct 19, 2021·Chembiochem : a European Journal of Chemical Biology·Congcong ZhangLin Li
Nov 12, 2021·Current Environmental Health Reports·Tess C Leuthner, Joel N Meyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.