Potential roles for the PIM1 kinase in human cancer - a molecular and therapeutic appraisal

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Nilesh ShahManuel Salto-Tellez

Abstract

In vitro experiments have shown the PIM1 kinase to have diverse biological roles in cell survival, proliferation and differentiation. In humans, PIM1 is often expressed in both normal and transformed cells. The PIM1 kinase is a true oncogene implicated in early transformation and tumour progression in haematopoietic malignancies and prostate carcinomas. It is associated with aggressive subgroups of lymphoma, is a marker of poor prognosis in prostate carcinomas and has been suggested to have a role in hormone insensitivity of prostate malignancies. PIM1 has a possible role in other carcinomas with 6p21 genomic alterations. On one hand, PIM1 (due to its role in malignancy) appears to be a promising target for drug development programmes but, on the other hand, the complexity of its molecular structure has posed challenges in the development of PIM1 inhibitors. In this review we discuss PIM1 expression in human tissues (including some new data from our laboratory), its role in human malignancies, as well as the possibilities and challenges in the development of target therapy for PIM1.

References

Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L NagarajanC M Croce
Jan 1, 1987·Gene·R Zakut-HouriA Telerman
Aug 10, 2000·European Journal of Biochemistry·H MaitaS M Iguchi-Ariga
Aug 24, 2001·Nature·S M DhanasekaranA M Chinnaiyan
Nov 6, 2001·American Journal of Respiratory Cell and Molecular Biology·R TempleR Jupp
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·X Peter ChenPaul Rothman
Jul 12, 2002·Chromosoma·Nandini BhattacharyaNancy S Magnuson
Nov 15, 2002·Biochimica Et Biophysica Acta·Zeping WangNancy S Magnuson
Feb 27, 2003·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Sven de VosH Phillip Koeffler
Aug 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·George WrightLouis M Staudt
May 18, 2004·International Journal of Cancer. Journal International Du Cancer·Camille C Rose RaginSusanne M Gollin
Jun 16, 2004·Cancer Metastasis Reviews·Quynh-Thu LeAmato J Giaccia
Jul 21, 2004·The Prostate·Alexander ValdmanLars Egevad
Sep 8, 2004·International Journal of Cancer. Journal International Du Cancer·Geoung A JeonMyung Hee Park
Feb 8, 2005·The International Journal of Biochemistry & Cell Biology·Malte Bachmann, Tarik Möröy
Aug 27, 2005·Molecular Cancer Research : MCR·Wei Wei ChenAndrew S Kraft
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chiung-Nien ChenFon-Jou Hsieh
Oct 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alain BarrierAntoinette Lemoine
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tae-Min KimYeun-Jun Chung
Mar 1, 2006·Journal of Clinical Pathology·T L CibullL Cheng
Jan 16, 2007·Molecular Cancer Therapeutics·Sheldon HolderMichael B Lilly
Jan 26, 2007·Bioorganic & Medicinal Chemistry Letters·I Wayne CheneyJim Z Wu
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Oleg FedorovStefan Knapp

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Citations

Dec 17, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Friedrich Luft
Dec 15, 2010·Nature Reviews. Cancer·Malia B Potts, Scott Cameron
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zanna BeharryAndrew S Kraft
Jan 27, 2010·The Journal of Biological Chemistry·Yun-Mi GohSuk-Chul Bae
May 25, 2012·Carcinogenesis·Maja Narlik-GrassowAmancio Carnero
Jan 26, 2012·Pancreas·Katherine M BlockAmanda F Baker
Mar 8, 2012·Molekuliarnaia biologiia·Iu N ZhukovaV N Danilenko
Dec 15, 2010·Journal of Experimental & Clinical Cancer Research : CR·Shengjie GuoShaopeng Qiu
Oct 6, 2010·Future Oncology·Nancy S MagnusonRaymond Reeves
Jan 15, 2015·Future Medicinal Chemistry·Bich Thuy LeShudong Wang
Oct 14, 2009·Cellular and Molecular Life Sciences : CMLS·Xiaochun Bai, Yu Jiang
Mar 6, 2012·Expert Opinion on Investigational Drugs·Anna Lena MerkelMatthias Ocker
Sep 26, 2012·Expert Opinion on Drug Discovery·Naoko OgawaAkiko Tanaka
Mar 10, 2015·Pharmacology & Therapeutics·Noel A Warfel, Andrew S Kraft
Oct 9, 2012·Biochemical Pharmacology·Carmen Blanco-Aparicio, Amancio Carnero
Sep 27, 2012·Hematology/oncology Clinics of North America·Warren FiskusKapil N Bhalla
Mar 5, 2016·Experimental Cell Research·Niina M SantioPäivi J Koskinen
Aug 11, 2010·Biochemical Pharmacology·Lisa S ChenVarsha Gandhi
Jun 4, 2013·Nucleic Acid Therapeutics·Ulrike WeirauchAchim Aigner
Jul 7, 2011·International Journal of Cancer. Journal International Du Cancer·Ryoko OkamotoH Phillip Koeffler
Apr 12, 2013·Medicinal Research Reviews·Maja Narlik-GrassowAmancio Carnero
Sep 10, 2015·Cancer Chemotherapy and Pharmacology·Richard A J DarbyRichard Callaghan
Aug 8, 2015·Inorganic Chemistry·Rajathees RajaratnamEric Meggers
Nov 13, 2012·Molecular and Cellular Endocrinology·Marjo MalinenJorma J Palvimo

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