Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair

Stem Cells International
Lihua LuoQingsong Ye

Abstract

This review summarizes current advances in dental pulp stem cells (DPSCs) and their potential applications in the nervous diseases. Injured adult mammalian nervous system has a limited regenerative capacity due to an insufficient pool of precursor cells in both central and peripheral nervous systems. Nerve growth is also constrained by inhibitory factors (associated with central myelin) and barrier tissues (glial scarring). Stem cells, possessing the capacity of self-renewal and multicellular differentiation, promise new therapeutic strategies for overcoming these impediments to neural regeneration. Dental pulp stem cells (DPSCs) derive from a cranial neural crest lineage, retain a remarkable potential for neuronal differentiation, and additionally express multiple factors that are suitable for neuronal and axonal regeneration. DPSCs can also express immunomodulatory factors that stimulate formation of blood vessels and enhance regeneration and repair of injured nerve. These unique properties together with their ready accessibility make DPSCs an attractive cell source for tissue engineering in injured and diseased nervous systems. In this review, we interrogate the neuronal differentiation potential as well as the neuroprotecti...Continue Reading

References

Nov 18, 1971·The New England Journal of Medicine·J Folkman
Mar 20, 1980·Nature·P M RichardsonA J Aguayo
Sep 2, 1998·Cell and Tissue Research·C C Stichel, H W Müller
Mar 31, 2000·Nature Medicine·P Carmeliet
Jun 15, 2000·Neurologia Medico-chirurgica·T MatsuyamaR Midha
Aug 22, 2000·The Journal of the American Academy of Orthopaedic Surgeons·S K Lee, S W Wolfe
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·S GronthosS Shi
Jul 31, 2002·Journal of Dental Research·S GronthosS Shi
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Songtao Shi, Stan Gronthos
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masako MiuraSongtao Shi
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Dec 15, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M E SughrueA L D'Ambrosio
May 14, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·C MorsczeckK H Hoffmann
May 20, 2006·Cellular and Molecular Neurobiology·Konstantin-Alexander Hossmann
Aug 26, 2006·Journal of Dental Research·L Tran-HungI About
Dec 5, 2006·Methods in Enzymology·Thomas A Reh, Andy J Fischer
Jan 18, 2007·Journal of Cellular Physiology·Antonio GiordanoIgnazio R Marino
Nov 9, 2007·Gene Therapy·B M Abdallah, M Kassem
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yi WangWei-dong Le
Mar 12, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Anderson Hsien-Cheng HuangAnthony Wing-Sang Chan
Apr 11, 2008·Cell Biology International·Annalisa PalmieriFrancesco Carinci
Apr 24, 2008·BMC Cell Biology·Pei-Hsun ChengAnthony W S Chan
Jul 5, 2008·Stem Cells·Peter J PsaltisStan Gronthos
Oct 22, 2008·Biomaterials·Olivier AlluinPatrick Decherchi
Apr 16, 2009·Vascular Medicine·Daniel P Sieveking, Martin K C Ng
Jun 23, 2009·Stem Cells·Agnieszka ArthurSimon A Koblar
Oct 3, 2009·Stem Cells and Development·Xing YanGeorge T-J Huang
Oct 10, 2009·Histochemistry and Cell Biology·Erdal KaraözAyla Eker Sariboyaci
Oct 14, 2009·International Journal of Immunopathology and Pharmacology·C MarchionniG P Bagnara
Dec 2, 2009·Journal of Cellular Biochemistry·Masanobu Ohishi, Ernestina Schipani
May 1, 2010·Nature Reviews. Drug Discovery·Martin Citron
Jun 18, 2010·Journal of Dental Research·N TamaokiK Tezuka

❮ Previous
Next ❯

Citations

Jul 28, 2019·Journal of Tissue Engineering and Regenerative Medicine·Maliheh JahromiAbbas Bakhtiari
Oct 28, 2019·Journal of Cellular Biochemistry·Rajasekaran SubbarayanSuresh Ranga Rao
Jan 23, 2020·Cellular and Molecular Life Sciences : CMLS·Xing-Liang FanQing-Ling Fu
Jul 8, 2020·Stem Cells Translational Medicine·Oscar O Solis-CastroMarcelo N Rivolta
Sep 21, 2018·Frontiers in Cellular Neuroscience·Eduardo Couve, Oliver Schmachtenberg
Aug 16, 2019·Cells·Yu HanJianxun Ding
Jul 30, 2020·Cell and Tissue Research·Duaa AbuarqoubAbdalla Awidi
Feb 6, 2020·Journal of Lasers in Medical Sciences·Malihe MirhosseiniShirin Farivar
May 18, 2020·International Journal of Molecular Sciences·Håvard Jostein HaugenJanne Elin Reseland
Jul 15, 2020·Biology·Shinichiro YoshidaHidefumi Maeda
Nov 28, 2019·Stem Cells International·Su-Min LeeHae-Hyoung Lee
Sep 10, 2020·Advanced Healthcare Materials·Shaowei GuoShulamit Levenberg
Oct 10, 2020·World Journal of Stem Cells·Cornelia Larissa Granz, Ali Gorji
Feb 4, 2021·Stem Cells Translational Medicine·Jennifer SotoSong Li
Nov 13, 2020·World Journal of Stem Cells·Dian-Ri WangWei-Dong Tian
Jan 13, 2021·International Journal of Molecular Sciences·Andrea LavoratoDiego Garbossa
Jan 30, 2021·Neural Regeneration Research·Nessma SultanBen A Scheven
Apr 4, 2021·International Journal of Molecular Sciences·Jon LuzuriagaGaskon Ibarretxe
May 29, 2021·Neurochemistry International·Eylem BaysalN Dilara Zeybek
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Kajohnkiart JanebodinMorayma Reyes Gil
Aug 7, 2021·Frontiers in Pharmacology·Keyue LiuBo Gao
Apr 30, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Meng LiYifu Guan
Nov 11, 2019·ACS Biomaterials Science & Engineering·Nandin MandakhbayarHae-Won Kim
Sep 19, 2021·Tissue Engineering and Regenerative Medicine·Hua-Nien LeeWei-Dong Tian
Sep 24, 2021·Stem Cell Reviews and Reports·M BousnakiP Koidis
Jan 5, 2022·ACS Biomaterials Science & Engineering·Michelle D DrewryFatima N Syed-Picard

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.