Potential roles of microRNAs in redox state: An update

Journal of Cellular Biochemistry
Habib YaribeygiAmirhossein Sahebkar

Abstract

Oxidative stress is an important underlying cause of many disease processes and may arise due to either increasing free radical generation or decreasing antioxidant defense systems. MicroRNAs (miRs) are 22-nucleotide non-coding RNAs that may regulate many intracellular processes; and, more recently, they have been implicated in the pathways for free radical generation leading to oxidative stress. However, conversely, there is evidence that miRs may have an antioxidant effect, thus miR expression may be critical for the maintenance of the normal redox state and cell homeostasis. This review addresses these discrepant and opposing miR actions on how they may modify and regulate the oxidative balance.

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Citations

Nov 26, 2019·Biochemistry. Biokhimii︠a︡·E V KalininaN N Chernov
Feb 29, 2020·Anti-cancer Agents in Medicinal Chemistry·Milad AshrafizadehAmirhossein Sahebkar
Sep 24, 2020·International Journal of Molecular Sciences·Adam WłodarskiAgnieszka Śliwińska
Oct 13, 2019·Life Sciences·Habib YaribeygiAmirhossein Sahebkar

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