Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions

doi:10.1016/j.bmcl.2009.05.064

PMID: 19524434DOI: 10.1016/j.bmcl.2009.05.064Jun 16, 2009

Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions

Bioorganic & Medicinal Chemistry Letters

H Bauke AlbadaRob M J Liskamp

Abstract

The antibiotic vancomycin-that binds lipid II in the bacterial cell membrane-was conjugated to a mono- and tetravalent mimic of the tris-histidine catalytic triad of metalloenzymes. Targeted hydrolysis by the conjugate was observed using model membranes containing lipid II, and in vitro MIC-values of the targeted mimic constructs could be modulated by Zn-ions.

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Citations

Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents

Jan 17, 2012·Journal of Medicinal Chemistry·Christopher J ArnuschYechiel Shai

Related Concepts

Lipid II

Antibiotics

Catalysis

Plasma Membrane

Hydrolysis

Imidazoles

Fungus Drug Sensitivity Tests

Uridine Diphosphate N-Acetylmuramic Acid

AB-Vancomycin

Bicyclo Compounds, Heterocyclic

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions

Abstract

References

The reaction between thiols and 8-azidoadenosine derivatives

Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic

Designed multiple ligands. An emerging drug discovery paradigm

Lipid II as a target for antibiotics

Parameters involved in antimicrobial and endotoxin detoxification activities of antimicrobial peptides

Multivalent carbohydrate recognition on a glycodendrimer-functionalized flow-through chip

The bacteria fight back

Hydrophobic side-chain length determines activity and conformational heterogeneity of a vancomycin derivative bound to the cell wall of Staphylococcus aureus

The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant Enterococci

Citations

Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents

Related Concepts

Related Feeds

Antifungals

Antifungals (ASM)

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