Potential targets for therapeutic intervention and structure based vaccine design against Zika virus

European Journal of Medicinal Chemistry
Amina QadirSyed Shahzad-Ul-Hussan

Abstract

Continuously increasing number of reports of Zika virus (ZIKV) infections and associated severe clinical manifestations, including autoimmune abnormalities and neurological disorders such as neonatal microcephaly and Guillain-Barré syndrome have created alarming situation in various countries. To date, no specific antiviral therapy or vaccine is available against ZIKV. This review provides a comprehensive insight into the potential therapeutic targets and describes viral epitopes of broadly neutralizing antibodies (bNAbs) in vaccine design perspective. Interactions between ZIKV envelope glycoprotein E and cellular receptors mediate the viral fusion and entry to the target cell. Blocking these interactions by targeting cellular receptors or viral structural proteins mediating these interactions or viral surface glycans can inhibit viral entry to the cell. Similarly, different non-structural proteins of ZIKV and un-translated regions (UTRs) of its RNA play essential roles in viral replication cycle and potentiate for therapeutic interventions. Structure based vaccine design requires identity and structural description of the epitopes of bNAbs. We have described different conserved bNAb epitopes present in the ZIKV envelope as pot...Continue Reading

Citations

Sep 24, 2020·Journal of Biomolecular Structure & Dynamics·Shubhangi Kandwal, Darren Fayne
Jul 29, 2019·Bioorganic & Medicinal Chemistry·Edeildo Ferreira da Silva-Júnior, João Xavier de Araújo-Júnior
Jul 14, 2020·Computers in Biology and Medicine·Hafsa IftikharSyed Shahzad-Ul-Hussan
Jul 19, 2021·European Journal of Medicinal Chemistry·Igor José Dos Santos NascimentoEdeildo Ferreira da Silva-Júnior
Oct 13, 2021·Journal of Medical Virology·Damiana Antônia de Fátima NunesJosé Carlos de Magalhães

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