Potential Targets for Treatment of Coronavirus Disease 2019 (COVID-19): A Review of Qing-Fei-Pai-Du-Tang and Its Major Herbs

The American Journal of Chinese Medicine
Linda Li Dan ZhongVivian Taam Wong

Abstract

COVID-19 has been declared a pandemic by WHO on March 11, 2020. No specific treatment and vaccine with documented safety and efficacy for the disease have been established. Hence it is of utmost importance to identify more therapeutics such as Chinese medicine formulae to meet the urgent need. Qing Fei Pai Du Tang (QFPDT), a Chinese medicine formula consisting of 21 herbs from five classical formulae has been reported to be efficacious on COVID-19 in 10 provinces in mainland China. QFPDT could prevent the progression from mild cases and shorten the average duration of symptoms and hospital stay. It has been recommended in the 6th and 7th versions of Clinical Practice Guideline on COVID-19 in China. The basic scientific studies, supported by network pharmacology, on the possible therapeutic targets of QFPDT and its constituent herbs including Ephedra sinica, Bupleurum chinense, Pogostemon cablin, Cinnamomum cassia, Scutellaria baicalensis were reviewed. The anti-oxidation, immuno-modulation and antiviral mechanisms through different pathways were collated. Two clusters of actions identified were cytokine storm prevention and angiotensin converting enzyme 2 (ACE2) receptor binding regulation. The multi-target mechanisms of QFPDT ...Continue Reading

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Citations

Jan 25, 2021·Journal of Ethnopharmacology·Zhonglei Wang, Liyan Yang
Nov 30, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Keng-Chang TsaiYi-Chang Su
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Jun 25, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Jul 16, 2021·The American Journal of Chinese Medicine·Yuting DuanZhaoxiang Bian

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