Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect

Journal of Traditional and Complementary Medicine
Anchalee PrasansuklabTewin Tencomnao

Abstract

Neurodegenerative diseases (NDD) are a range of debilitating conditions of the brain involving progressive loss of neurons, many of which are still currently incurable despite enormous efforts on drug discovery and development in the past decade. As NDD is closely linked to old age, the rapid worldwide growth in the aging population contributes to an increasing number of people with one of these incurable diseases and therefore it is considered a significant global health issue. There is an urgent need for novel effective treatments for NDD, and many new research strategies are centered on traditional medicine as an alternative or complementary solution. Several previous findings have suggested that glutamate toxicity drives neurodegeneration in many NDD, and the medicinal plants with anti-glutamate toxicity properties can be potentially used for their treatment. In order to obtain data relating to natural products against glutamate toxicity, six candidate plant species of Thailand were identified. Studies utilizing these herbs were searched for using the herb name (Latin and common names) along with the term "glutamate" in the following databases across all available years: PubMed, Scopus, and Google Scholar. This review empha...Continue Reading

Citations

Aug 19, 2020·Biomedicines·Andleeb KhanMuneeb U Rehman
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·O New LeeIyyakkannu Sivanesan

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BETA
nuclear translocation

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