Potential therapeutic applications of the gut microbiome in obesity: from brain function to body detoxification.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Béatrice S-Y ChoiAngelo Tremblay

Abstract

The prevalence of obesity is rising every year and associated comorbidities such as cardiovascular diseases are among the leading causes of death worldwide. The gut microbiota has recently emerged as a potential target for therapeutic applications to prevent and treat those comorbidities. In this review, we focus on three conditions related to obesity in which the use of gut microbiota modulators could have benefits; mood disorders, eating behaviors, and body detoxification of persistent organic pollutants (POPs). On one hand, modulation of gut-derived signals to the brain in a context of obesity is involved in the development of neuroinflammation and can subsequently alter behaviors. An altered gut microbiome could change these signals and alleviate their consequences. On the other hand, obesity is associated with an increased accumulation of lipophilic contaminants, such as POPs. Targeting the microbiota could help body detoxication by reducing bioavailability, enhancing degradation by bioremediation or their excretion through the enterohepatic circulation. Thus, a supplementation of prebiotics, probiotics, or synbiotics could represent a complementary strategy to current ones, such as medication and lifestyle modifications, ...Continue Reading

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Citations

Nov 2, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Béatrice So-Yun ChoiAndré Marette
Jun 3, 2021·Microorganisms·Chunye ZhangAaron C Ericsson
Aug 29, 2021·Nature Reviews. Gastroenterology & Hepatology·Daniel A SchupackPurna C Kashyap
Sep 8, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Lili LiSong Qin

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