Potential therapeutic approaches for a sleeping pathogen: tuberculosis a case for bioinorganic chemistry.

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Eduardo H S SousaJosé J G Moura

Abstract

Mycobacterium tuberculosis (Mtb) has an old history as a human pathogen and still kills over one million people every year. One key feature of this bacterium is its dormancy: a phenomenon responsible for major changes in its metabolism and replication that have been associated with the need for a lengthy therapy for Mtb. This process is regulated by key heme-based sensors, particularly DosT and DevS (DosS), among other co-regulators, and also linked to nitrogen utilization (nitrate/nitrite) and stringent responses. In face of the current threat of tuberculosis, there is an urgent need to develop new therapeutic agents capable of targeting the dormant state, associated with the need for a lengthy therapy. Interestingly, many of those key proteins are indeed metallo-containing or metallo-dependent biomolecules, opening exciting bioinorganic opportunities. Here, we critically reviewed a series of small molecules targeting key proteins involved in these processes, including DosT/DevS/DevR, RegX3, MprA, MtrA, NarL, PknB, Rel, PPK, nitrate and nitrite reductases, GlnA1, aiming for new opportunities and alternative therapies. In the battle against Mycobacterium tuberculosis, new drug targets must be searched, in particular  those invo...Continue Reading

References

Jan 25, 2000·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·L G Wayne, L G Hayes
Mar 29, 2001·Journal of Bacteriology·C BoonT Dick
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·T C Zahrt, V Deretic
Aug 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·John L DahlClifton E Barry
Feb 14, 2004·Organic Letters·Lilu ZhangEric Meggers
Mar 23, 2004·The Journal of Biological Chemistry·David M RobertsDavid R Sherman
Jun 23, 2004·Tuberculosis·D G Niranjala MuttucumaruTanya Parish
Sep 9, 2004·The Journal of Experimental Medicine·Petros C KarakousisWilliam R Bishai
Jun 26, 2007·Molecular Microbiology·Riccardo Manganelli
Jun 30, 2007·Protein Science : a Publication of the Protein Society·Eduardo Henrique Silva SousaMarie-Alda Gilles-Gonzalez
Jul 17, 2007·Molecular Microbiology·Kamakshi SurekaManikuntala Kundu
Oct 4, 2007·The Journal of Biological Chemistry·Mathew SajishBalaji Prakash
Apr 25, 2008·Methods in Enzymology·Marie-Alda Gilles-GonzalezJason Tuckerman
Oct 24, 2008·PloS One·Jesús Gonzalo-AsensioCarlos Martín
Jul 7, 2009·Annual Review of Microbiology·Rong Gao, Ann M Stock
Aug 4, 2009·European Journal of Medicinal Chemistry·Pawan GuptaPrabha Garg
Aug 19, 2009·The Journal of Infectious Diseases·Dalin RifatPetros C Karakousis
Oct 16, 2009·Journal of Medicinal Chemistry·Rajesh Kumar GuptaJaya Sivaswami Tyagi
Oct 22, 2009·Molecular Microbiology·Kamakshi SurekaManikuntala Kundu
Jan 6, 2010·EMBO Molecular Medicine·Jacqueline Njoroge, Vanessa Sperandio
Jan 19, 2010·Nature Reviews. Drug Discovery·David A Rasko, Vanessa Sperandio
Sep 25, 2010·The Journal of Infectious Diseases·Lee G KlinkenbergPetros C Karakousis
Nov 26, 2010·European Journal of Medicinal Chemistry·Gabin Mwande MagueneLydie Pélinski
Mar 1, 2012·Journal of Medicinal Chemistry·Johan GisingAnders Karlén
Mar 1, 2012·FEMS Microbiology Letters·Sakshi DhingraJaya S Tyagi
Apr 4, 2012·Bioorganic & Medicinal Chemistry Letters·Timothy M ChapmanDavid Whalley
Oct 3, 2012·PLoS Pathogens·Ezequiel WexselblattSigal Ben-Yehuda

❮ Previous
Next ❯

Citations

Nov 27, 2020·International Journal of Molecular Sciences·André CampaniçoFrancisca Lopes

❮ Previous
Next ❯

Methods Mentioned

BETA
phage-display
SELEX

Software Mentioned

DevS
DosT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Chemical Biology
Joan B Broderick, Dimitri Coucouvanis
Journal of Cellular Biochemistry
T D Tullius
Current Opinion in Chemical Biology
A J Thomson, H B Gray
© 2021 Meta ULC. All rights reserved