Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review

Phytotherapy Research : PTR
Milad AshrafizadehSaeed Samarghandian

Abstract

Curcumin is a naturally occurring nutraceutical compound with a number of therapeutic and biological activities such as antioxidant, anti-inflammatory, anti-diabetic, antitumor, and cardioprotective. This plant-derived chemical has demonstrated great potential in targeting various signaling pathways to exert its protective effects. Signal transducers and activator of transcription (STAT) is one of the molecular pathways involved in a variety of biological processes such as cell proliferation and cell apoptosis. Accumulating data demonstrates that the STAT pathway is an important target in treatment of a number of disorders, particularly cancer. Curcumin is capable of affecting STAT signaling pathway in induction of its therapeutic impacts. Curcumin is able to enhance the level of anti-inflammatory cytokines and improve inflammatory disorders such as colitis by targeting STAT signaling pathway. Furthermore, studies show that inhibition of JAK/STAT pathway by curcumin is involved in reduced migration and invasion of cancer cells. Curcumin normalizes the expression of JAK/STAT signaling pathway to exert anti-diabetic, renoprotective, and neuroprotective impacts. At the present review, we provide a comprehensive discussion about th...Continue Reading

References

Aug 1, 1978·Acta Pharmacologica Et Toxicologica·B Wahlström, G Blennow
Dec 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G M HolderA J Ryan
Feb 1, 1991·Planta medica·H P Ammon, M A Wahl
Dec 1, 1993·Molecular and Cellular Biology·M DavidA C Larner
Jun 13, 2000·Oncogene·T Decker, P Kovarik
May 10, 2001·International Journal of Hematology·W J Leonard
Sep 13, 2001·Stem Cells·D L Krebs, D J Hilton
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan S BielackKurt Winkler
Jun 1, 2002·Science·David S Aaronson, Curt M Horvath
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·David E Levy, J E Darnell
Jul 24, 2003·Nature Reviews. Immunology·Gerd Bouma, Warren Strober
Nov 8, 2003·World Journal of Gastroenterology : WJG·Ai-Jun ZhuXue-Jun Sun
Mar 17, 2004·Journal of Cell Science·Jason S RawlingsDouglas A Harrison
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ricky A SharmaWilliam P Steward
Oct 20, 2005·American Journal of Physiology. Renal Physiology·Takahiko NakagawaRichard J Johnson
Mar 21, 2006·BMC Complementary and Alternative Medicine·Christopher D LaoDean E Brenner
Jul 25, 2006·Cancer Treatment Reviews·Alessandra LonghiGaetano Bacci
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter J Murray
Apr 3, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kuo-Yi YangTung-Hu Tsai
May 30, 2007·Gastroenterology Clinics of North America·Georgios I PapachristouDavid C Whitcomb
Jun 5, 2007·Current Opinion in Gastroenterology·Giorgos Bamias, Fabio Cominelli
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Jun 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shaiju K VareedDean E Brenner
Apr 18, 2009·Srpski arhiv za celokupno lekarstvo·Gordana Konjević
Apr 22, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yuko IwakamiToshifumi Hibi
Feb 25, 2010·Reviews in Endocrine & Metabolic Disorders·Sihem Boudina, Evan Dale Abel
Mar 3, 2010·Molecular Neurobiology·Lih-Fen LueDouglas G Walker
Mar 13, 2010·Expert Review of Endocrinology & Metabolism·Frank C BrosiusSheldon Chen
May 18, 2010·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Stephen Y Lai, Faye M Johnson
May 20, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Anastasia A Varvarigou
Sep 9, 2010·International Journal of Cancer. Journal International Du Cancer·Suksanti PrakobwongSomchai Pinlaor
Dec 4, 2010·Investigational New Drugs·Sridurga MithraprabhuAndrew Spencer
Mar 5, 2011·Cancer Prevention Research·Robert E CarrollDean E Brenner
Apr 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Azam HassaninasabMichihiko Kobayashi
Dec 6, 2011·Annual Review of Immunology·Ralph M Steinman

❮ Previous
Next ❯

Citations

Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sun Young MoonCheol Hwangbo
Jul 3, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Liang WangDapeng Chen
Jul 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yaw-Syan FuChing-Feng Weng
Jul 11, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sepideh MirzaeiGautam Sethi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.