Potential therapeutic effects of oral bisphosphonates on the intestine

Annals of the New York Academy of Sciences
M Pazianas, R Graham G Russell

Abstract

Bisphosphonates are the principal drugs prescribed for the prevention of osteoporotic fractures. They are bone specific but poorly absorbed. In oral formulations, almost 99% of the administered dose remains within the intestinal tract and reaches the small and large bowel. Although the nitrogen-containing bisphosphonates can irritate the distal esophageal/gastric mucosa, they improve drug-induced colitis in animal models and exhibit antitumor properties on intestinal cells in vitro. Several recent epidemiological studies provide evidence of a reduced risk of colorectal cancer in osteoporotic patients treated with oral bisphosphonates, notably alendronate. In this review, we will explore the possible mechanisms of action underlying these effects and raise the question of whether these agents might be used in the chemoprophylaxis against colorectal cancer.

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Citations

Mar 7, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M PazianasR Graham G Russell
May 31, 2014·BoneKEy Reports·Michael PazianasPaul Miller
Dec 12, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghPaul J Limburg
Apr 19, 2013·British Journal of Clinical Pharmacology·Stefanos BonovasPantelis Bagos
Feb 26, 2013·Current Opinion in Pharmacology·Anne Pernille Hermann, Bo Abrahamsen
Aug 20, 2015·Therapeutic Advances in Musculoskeletal Disease·Pia Eiken, Peter Vestergaard
Apr 23, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K R OlsenB Abrahamsen
Jul 28, 2019·British Journal of Pharmacology·Thomas M Tzschentke
Oct 24, 2014·World Journal of Gastroenterology : WJG·Luca Petruccio PiodiFabio Massimo Ulivieri
Jan 27, 2016·World Journal of Gastroenterology : WJG·Celina AngAndrea Branch

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