Potential Therapeutic Role of Dietary Supplementation with Spirulina platensis on the Erectile Function of Obese Rats Fed a Hypercaloric Diet

Oxidative Medicine and Cellular Longevity
Anderson F A DinizBagnólia A da Silva

Abstract

Spirulina platensis, an important source of bioactive compounds, is a multicellular, filamentous cyanobacterium rich in high-quality proteins, vitamins, minerals, and antioxidants. Due to its nutrient composition, the alga is considered a complete food and is recognized for its anti-inflammatory, antioxidant, antiobesity, and reproprotective effects. All of which are important for prevention and treatment of organic and metabolic disorders such as obesity and erectile dysfunction. The aim of this study was to investigate the modulatory role of Spirulina platensis food supplementation and the mechanisms of action involved in reversing the damage caused by a hypercaloric diet on the erectile function of rats. The animals were divided into a standard diet group (SD, n = 5); a hypercaloric diet group (HCD, n = 5); a hypercaloric diet group supplemented with S. platensis at doses of 25 (HCD+SP25, n = 5), 50 (HCD+SP50, n = 5), and 100 mg/kg (HCD+SP100, n = 5); and a hypercaloric diet group subsequently fed a standard diet (HCD+SD, n = 5). In the rats fed a hypercaloric diet, dietary supplementation with S. platensis effectively increased the number of erections while decreasing latency to initiate penile erection. Additionally, S. pl...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Apr 10, 1999·Journal of Nutritional Science and Vitaminology·O HayashiY Okuwaki
Dec 21, 2000·Free Radical Biology & Medicine·A GhiselliC Scaccini
Mar 18, 2003·Life Sciences·Olivier RampinCharles Suaudeau
Dec 6, 2003·Pharmacological Reviews·Richard R NeubigUNKNOWN International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification
Feb 14, 2004·Nutrition·Debora EstadellaClaudia M Oller Do Nascimento
May 12, 2004·Urology·Mário A ClaudinoAngelina Zanesco
Dec 7, 2005·Journal of Hypertension·Johanna L HannanMichael A Adams
Apr 19, 2006·Phytotherapy Research : PTR·M RadenkovicS Veljkovic
Sep 22, 2006·Antioxidants & Redox Signaling·Dean P Jones
Jan 25, 2007·The Journal of Pharmacology and Experimental Therapeutics·Yolanda AlvarezMercedes Salaices
Aug 19, 2007·International Journal of Impotence Research·L VignozziM Maggi
Jan 23, 2008·The Journal of Sexual Medicine·Liming JinArthur L Burnett
Jun 6, 2009·Obesity·Andreas SchwiertzPhilip D Hardt
Jul 21, 2009·Urology·Fermino S LizarteLuis F Tirapelli
Oct 3, 2009·The Journal of Sexual Medicine·Julio Eduardo FerrerAna Milena Herrera
Jan 12, 2010·The Journal of Sexual Medicine·Nuno TomadaDelminda Neves
Jun 1, 2010·Journal of Agricultural and Food Chemistry·Jun LuMasaru Tanokura
Jul 17, 2010·Cardiovascular Therapeutics·Ruitang Deng, Te-Jin Chow
Feb 22, 2013·Circulation·Sanjana DayalSteven R Lentz
Jun 12, 2013·Journal of the Science of Food and Agriculture·Elias E MazokopakisEmmanuel S Ganotakis
Sep 14, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Fábio H SilvaEdson Antunes
Oct 11, 2014·Journal of Neural Transmission·Félix Javier Jiménez-JiménezJosé A G Agúndez
Oct 2, 2015·Environmental Science and Pollution Research International·Mayada R FaragSahar A Ahmed
Oct 5, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Maria-Corina SerbanMaciej Banach
Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohamed Abdel-DaimAhmed M Hassan
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Balazs Antus
Jun 3, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Benjumin HsuRobert G Cumming
Jun 18, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kadry M SadekMoustafa Shoukry

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Citations

Jul 21, 2021·The Journal of Sexual Medicine·Tomoya KataokaKazunori Kimura
Aug 10, 2021·Oxidative Medicine and Cellular Longevity·Anderson Fellyp Avelino DinizBagnólia Araújo da Silva

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