Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype

Oncotarget
Fangyuan ShaoChu-Xia Deng

Abstract

Triple-negative breast cancer (TNBC) is an aggressive subgroup of human breast cancer, which is characterized as estrogen receptor (ER) negative, progesterone receptor (PR) negative, and human epidermal growth factor receptor 2 (HER2) negative. TNBC is the most difficult breast cancer subgroup to treat, due to its unresponsiveness to current clinical targeted therapies, high rate of recurrence, and poor prognosis. Thus, there is an urgent medical need to identify therapeutic targets and develop more effective stratified medicine for the treatment of TNBC. Here we review the potential therapeutic targets for TNBC based on its intrinsic subtype. We also review the aberrant activated signals found in different subgroups of TNBC, including androgen receptor (AR) and PI3K/AKT/mTOR, Notch, Wnt/β-catenin, Hedge-hog, and TGF-β signaling pathways, which play essential roles in multiple development stages of TNBC. The careful analysis of these signaling pathways and therapeutic targets would have significant impact on the drug development and clinical trials, leading to effective therapies for this deadly disease.

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Citations

Jan 11, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuhui WangXiaoqun Duan
Jan 10, 2019·Journal of Cellular Physiology·Zhi-Dong LvFu-Nian Li
Oct 27, 2018·Journal of Cellular Biochemistry·Mohamed A Abdel-MohsenMarihan A Helal
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Jun 28, 2020·Scientific Reports·Charu KothariFrancine Durocher
Jan 21, 2021·International Journal of Molecular Sciences·Yueyuan ZhouTakahiro Ochiya
May 25, 2021·Computational and Structural Biotechnology Journal·Desh Deepak SinghDharmendra Kumar Yadav

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Methods Mentioned

BETA
methylation capture sequencing
xenograft
transgenic
xenografts

Clinical Trials Mentioned

NCT01945775
NCT02163694
NCT02892734
NCT02563925
NCT02838823
NCT02129556
NCT02511847
NCT01732276
NCT01097642
NCT01520389

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