PMID: 8946301Dec 1, 1996Paper

Potential treatment modalities for glaucomatous neuropathy: neuroprotection and neuroregeneration

Journal of Glaucoma
M SchwartzA Solomon

Abstract

This article presents the rationale and an experimental strategy for the development of new treatment modalities for glaucomatous neuropathy. Accumulating evidence suggests that regardless of the primary trigger of the retinal and optic nerve damage in glaucoma, the disease will continue to progress even when the cause is removed. The resulting damage can be mimicked by the progression of damage secondary to an acute partial crush injury at the optic nerve head. Such secondary damage includes degeneration of the directly injured optic nerve fibers culminating in death of their cell bodies, as well as degeneration of nerve fibers that escaped acute injury but nevertheless deteriorate as a result of their exposure to injury-induced mediators of secondary degeneration released by the directly affected neurons. We therefore propose that substances found to be effective in rescuing fibers from secondary degeneration and in increasing the survival rate or prolonging survival of retinal ganglion cells in the partially lesioned optic nerve may be useful for the treatment of glaucoma. The new approach does not replace hypotensive therapy, but addresses the glaucoma-induced damage by promoting nerve protection and neuroregeneration.

Citations

Jan 10, 2002·Journal of Neuroscience Research·Pawel Grieb, Robert Rejdak
Aug 13, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sharon BakalashMichal Schwartz
Sep 21, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S ThalerF Schuettauf
Jul 23, 1999·Survey of Ophthalmology·P L KaufmanM Cynader
Jul 23, 1999·Survey of Ophthalmology·N N OsborneM S Nash
May 29, 2000·Immunology Today·M Schwartz, I R Cohen
Mar 24, 2004·Brain Research Bulletin·Michal Schwartz
Mar 24, 2004·Brain Research Bulletin·Michal Schwartz
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·P L Kaufman
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J KipnisM Schwartz
May 4, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Henry H L ChanKwok-Fai So
Jul 22, 1999·The British Journal of Ophthalmology·N N OsborneM S Nash
Jul 17, 2003·Journal of Postgraduate Medicine·S KaushikJ Ram
Dec 25, 2002·Journal of Cataract and Refractive Surgery·Joann Y NevyasAnita Nevyas-Wallace
Jul 5, 2005·Expert Opinion on Investigational Drugs·R David
Apr 20, 2016·Frontiers in Aging Neuroscience·Pawel GriebRobert Rejdak
Dec 30, 2014·BMC Ophthalmology·William S FoulshamAndrew J Tatham
Sep 6, 2005·Survey of Ophthalmology·O V KubayG L Raymond
Mar 15, 2006·Experimental Eye Research·Elaine C JohnsonJohn C Morrison
Jan 15, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Doreen SchmidlAlina Popa-Cherecheanu
Jul 14, 2016·The Journal of Comparative Neurology·Abram AkopianStewart A Bloomfield
May 18, 2011·Clinical & Experimental Ophthalmology·Banu BozkurtIlhan Tezcan
Jan 26, 2017·The Cochrane Database of Systematic Reviews·Dayse F Sena, Kristina Lindsley

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