Potential treatments for genetic hearing loss in humans: current conundrums

Gene Therapy
R MinodaH Takeda

Abstract

Genetic defects are a major cause of hearing loss in newborns. Consequently, hearing loss has a profound negative impact on human daily living. Numerous causative genes for genetic hearing loss have been identified. However, presently, there are no truly curative treatments for this condition. There have been several recent reports on successful treatments in mice using embryonic gene therapy, neonatal gene therapy and neonatal antisense oligonucleotide therapy. Herein, we describe state-of-the-art research on genetic hearing loss treatment through gene therapy and discuss the obstacles to overcome in curative treatments of genetic hearing loss in humans.

References

Apr 7, 1999·Nature Genetics·D A ScottL P Karniski
Jun 4, 1999·Trends in Neurosciences·D M Fekete
Apr 7, 2000·Brain Research. Brain Research Reviews·C M Frenz, T R Van De Water
Feb 24, 2001·Journal of Perinatology : Official Journal of the California Perinatal Association·J W Hall
Feb 24, 2001·American Journal of Physiology. Renal Physiology·M SoleimaniC E Burnham
Mar 20, 2001·Developmental Biology·C V Baker, M Bronner-Fraser
Jan 25, 2002·The New England Journal of Medicine·Ignacio del CastilloFelipe Moreno
Aug 13, 2002·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Aileen KennesonColeen Boyle
Aug 16, 2002·Genetics in Medicine : Official Journal of the American College of Medical Genetics·UNKNOWN ACMG
Sep 27, 2002·British Medical Bulletin·Jane BryantGuy P Richardson
Dec 19, 2002·Otolaryngologic Clinics of North America·Stephen W Hone, Richard J H Smith
Dec 20, 2002·Human Molecular Genetics·Barbara TeubnerKlaus Willecke
Aug 15, 2003·The New England Journal of Medicine·Vincent MichelChristine Petit
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lily NgDouglas Forrest
Mar 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·James E SylvesterThomas W O'Brien
May 7, 2004·Neuroreport·Ryosei MinodaYehoash Raphael
Oct 28, 2004·The Journal of Molecular Diagnostics : JMD·Iris Schrijver
Mar 9, 2005·Lancet·Richard J H SmithKarl R White
Sep 20, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuhe LiuKeiya Ozawa
May 19, 2006·The New England Journal of Medicine·Cynthia C Morton, Walter E Nance
Oct 21, 2006·Nature Reviews. Neuroscience·Matthew W Kelley
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shuping JiaDavid Z Z He
Oct 4, 2011·The Journal of Clinical Investigation·Byung Yoon ChoiAndrew J Griffith
Nov 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Taku ItoAndrew J Griffith
Jan 19, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Giovanni MonteleoneFrancesco Pallone
Dec 26, 2012·Hearing Research·Hideto Fukui, Yehoash Raphael
Apr 17, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Toru MiwaEiji Yumoto
May 15, 2013·International Journal of Audiology·Tiago Daniel MatosGraça Fialho

❮ Previous
Next ❯

Citations

Jun 15, 2017·Neuroreport·Jing-Ying GuoShu-Sheng Gong
Jan 7, 2020·Médecine sciences : M/S·Jean-Pierre Hardelin, Saaid Safieddine
Aug 18, 2017·Journal of the Association for Research in Otolaryngology : JARO·Hena AhmedJeffrey R Holt
Feb 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Omar AkilLawrence R Lustig
Nov 30, 2016·Molecular Genetics & Genomic Medicine·Arti Pandya
Jun 27, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuanyuan XueYilai Shu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

Inquiry : a Journal of Medical Care Organization, Provision and Financing
J Hadley
Risk Analysis : an Official Publication of the Society for Risk Analysis
Wout Slob
Bulletin of the World Health Organization
P J Morris
© 2021 Meta ULC. All rights reserved