Potential use of cytokine therapy in poultry

Veterinary Immunology and Immunopathology
J W LowenthalM Digby

Abstract

Newly hatched chickens are highly susceptible to infection during the first 2 weeks of life. The utilisation of cytokines as therapeutic agents in livestock animals, in particular poultry, has become more feasible with the recent cloning of cytokine genes and the progression of new technologies such as live vectors. We have constructed a live recombinant fowlpox virus (FPV) that expresses chicken myelomonocytic growth factor (fp/cMGF). Administration of fp/cMGF to chicks resulted in a marked and sustained increase in the number of circulating blood monocytes as well as an increase in their state of activation, as measured by enhanced phagocytic activity and elevated production of nitric oxide. We have recently cloned the gene for chicken interferon-gamma (ChIFN-gamma). Recombinant ChIFN-gamma was capable of protecting chick fibroblasts from undergoing virus-mediated lysis and induced nitrite secretion from chicken macrophages in vitro. Preliminary vaccination trials have indicated that co-administration of ChIFN-gamma with antigen (sheep red blood cells) resulted in enhanced secondary (IgG) antibody responses and allowed a 10-fold lower dose of antigen to be used. Furthermore, administration of ChIFN-gamma resulted in enhanced ...Continue Reading

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Citations

Feb 26, 2000·Developmental and Comparative Immunology·C Siatskas, R Boyd
Mar 16, 2000·Developmental and Comparative Immunology·W I MuirA J Husband
Sep 1, 2000·Advanced Drug Delivery Reviews·K Ciftci, P Trovitch
Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·H Y YehJ M Sharma
Nov 19, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yufang YangRoys S Sundick
Jan 8, 2004·The Journal of Veterinary Medical Science·Kazuaki TakeharaMasayuki Nakamura
May 28, 2013·Developmental and Comparative Immunology·Pengju GuoJohn W Lowenthal
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Inui
Mar 23, 2004·Endocrinology·Randip K BainsIain C A F Robinson

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