PMID: 9664163Jul 17, 1998Paper

Potential use of granulocyte colon-stimulating factor and granulocyte-macrophage colony-stimulating factor in neonates

Current Opinion in Hematology
F BrachoM S Cairo

Abstract

The immaturity of neonatal phagocytic immunity contributes to increased mortality during neonatal sepsis. Neonates have both quantitative and qualitative neutrophil defects with decreased bone marrow neutrophil storage pool (NSP) reserves, an inability to increase neutrophil production, and defective neutrophil functional activity. Neonates respond to overwhelming sepsis with depletion of the NSP and the development of peripheral neutropenia. The myelopoietic cytokines granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been documented to induce neutrophilia in neonatal animals and human infants, increase the NSP, and upregulate neutrophils for improved functional activity. Preclinical studies in neonatal rats demonstrate increased survival with prophylactic G-CSF during experimental group B streptococcal sepsis. In pilot phase I/II human trials, G-CSF and GM-CSF were demonstrated to be both safe and well tolerated and to induce significant increases in absolute neutrophil count and NSP. Prophylactic GM-CSF in the very low birth weight neonate may reduce the incidence of nosocomial infections. Phase III trials are needed to further delineate the clinical usefulness of...Continue Reading

Citations

Aug 21, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tsan-Tzu YangChiou-Feng Lin
Apr 26, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·A R Bedford RussellE G Davies
Oct 10, 2009·Veterinary Immunology and Immunopathology·Eugene H JohnsonRashid Al-Busaidy
Dec 17, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gwynn D LongNelson J Chao
Feb 25, 2003·Critical Care Nursing Clinics of North America·Judy Wright Lott
Jul 16, 2005·Stem Cells·Ouassila HabiMadeleine Carreau
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A VarasA Vicente

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