PMID: 11918519Mar 29, 2002Paper

Potential use of HMG-CoA reductase inhibitors for osteoporosis

The Annals of Pharmacotherapy
Lolita M Cushenberry, Magaly Rodriguez de Bittner

Abstract

To review the current clinical data describing the effects of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in bone formation and reduction of fracture incidence and their potential use for osteoporosis. English-language articles and abstracts were identified from a MEDLINE database search (1966-May 2001) that used the key words osteoporosis, HMG-CoA reductase inhibitors, and treatment. All the articles identified from the data sources were evaluated, and all information deemed relevant was included in this review. In the past, there has been considerable emphasis placed in the detection, prevention, and treatment of osteoporosis. New drug therapies have been introduced in the market aimed at decreasing bone loss and increasing bone formation, with the ultimate goal of decreasing fractures. Currently, there are a variety of agents available for the treatment of osteoporosis. A limited number of case-control studies have suggested that HMG-CoA reductase inhibitors (statins) may have the potential to reduce the risk of fractures by increasing bone formation, although other studies have failed to show a benefit in fracture reduction. The potential benefit of this therapy is still undetermined because of a lack of...Continue Reading

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Citations

Feb 24, 2007·The American Journal of Cardiology·James S Forrester, Peter Libby
Mar 16, 2005·Pharmacotherapy·Michael J Gonyeau
Apr 17, 2003·Drugs & Aging·Raymond G Schlienger, Christoph R Meier
Oct 20, 2005·Journal of Biomolecular Screening·Angeleen FlemingPaul Goldsmith
Jul 24, 2012·Regenerative Medicine·Kevin W-H LoCato T Laurencin
Apr 20, 2012·Advanced Drug Delivery Reviews·Kevin W-H LoCato T Laurencin

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