Potential use of microarray technology for rapid identification of central nervous system pathogens

Military Medicine
Eric H HansonRobb K Rowley

Abstract

Outbreaks of central nervous system (CNS) diseases result in significant productivity and financial losses, threatening peace and wartime readiness capabilities. To meet this threat, rapid clinical diagnostic tools for detecting and identifying CNS pathogens are needed. Current tools and techniques cannot efficiently deal with CNS pathogen diversity; they cannot provide real-time identification of pathogen serogroups and strains, and they require days, sometimes weeks, for examination of tissue culture. Rapid and precise CNS pathogen diagnostics are needed to provide the opportunity for tailored therapeutic regimens and focused preventive efforts to decrease morbidity and mortality. Such diagnostics are available through genetic and genomic technologies, which have the potential for reducing the time required in serogroup or strain identification from 500+ hours for some viral cultures to less than 3 hours for all pathogens. In the near future, microarray diagnostics and future derivations of these technologies will change the paradigm used for outbreak investigations and will improve health care for all.

Citations

Mar 17, 2010·Journal of Veterinary Emergency and Critical Care·Peter P Nghiem, Scott J Schatzberg
Jan 27, 2007·Microbial Cell Factories·Pratik JaluriaJoseph Shiloach
Jun 28, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ren-Jy BenYao-Dung Hsieh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Central Nervous System Bacterial Infections

Central nervous system bacterial infections are medical emergencies and include bacterial meningitis and spinal epidural abscess. Treatment with antibiotics can reduce morbidity and mortality. Discover the latest research on central nervous system bacterial infections here.

Related Papers

BMJ : British Medical Journal
A Vass
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
Steinar Westin
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
Tordis Sørensen Høifødt, Bjørn Hilt
Heart & Lung : the Journal of Critical Care
M D Fowler
© 2021 Meta ULC. All rights reserved