Potential use of noncoding RNAs and innovative therapeutic strategies to target the 5'UTR of SARS-CoV-2

Epigenomics
Antonella BaldassarreAndrea Masotti

Abstract

After the increasing number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections all over the world, researchers and clinicians are struggling to find a vaccine or innovative therapeutic strategies to treat this viral infection. The severe acute respiratory syndrome coronavirus infection that occurred in 2002, Middle East respiratory syndrome (MERS) and other more common infectious diseases such as hepatitis C virus, led to the discovery of many RNA-based drugs. Among them, siRNAs and antisense locked nucleic acids have been demonstrated to have effective antiviral effects both in animal models and humans. Owing to the high genomic homology of SARS-CoV-2 and severe acute respiratory syndrome coronavirus (80-82%) the use of these molecules could be employed successfully also to target this emerging coronavirus. Trying to translate this approach to treat COVID-19, we analyzed the common structural features of viral 5'UTR regions that can be targeted by noncoding RNAs and we also identified miRNAs binding sites suitable for designing RNA-based drugs to be employed successfully against SARS-CoV-2.

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S MakinoM M Lai
Oct 23, 1998·Advances in Experimental Medicine and Biology·S G Sawicki, D L Sawicki
May 6, 2003·Science·Marco A MarraRachel L Roper
Feb 28, 2004·FEBS Letters·Yuanjiang ZhangZhijie Chang
Mar 24, 2004·Nature Reviews. Microbiology·Konrad StadlerRino Rappuoli
Jan 18, 2005·Antiviral Research·Chang-Jer WuYi-Lin Chan
Jan 26, 2006·Expert Opinion on Investigational Drugs·Chang-Jer Wu, Yi-Lin Chan
Aug 25, 2006·Journal of Virology·Stanley G SawickiStuart G Siddell
Jan 31, 2007·Gene Therapy·Z Chang, Z Hu
Jun 2, 2007·Nature Reviews. Drug Discovery·Antonin de FougerollesJudy Lieberman
Sep 26, 2007·Nature Genetics·Michael KerteszEran Segal
Feb 22, 2008·Journal of Molecular Biology·Lichun LiDavid P Giedroc
Aug 12, 2008·FEBS Letters·Mariola DutkiewiczJens Kurreck
Oct 20, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying WangLi Liu
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Erica S MachlinSelena M Sagan
Aug 3, 2012·Nucleic Acid Therapeutics·Robert StantonRobert Dullea
Mar 28, 2013·Journal of Drug Delivery·Federico Perche, Vladimir P Torchilin
Mar 29, 2013·The New England Journal of Medicine·Harry L A JanssenMichael R Hodges
Apr 9, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eveline P van PoelgeestJacobus Burggraaf
Aug 3, 2013·Annals of Neurology·Jerry R MendellUNKNOWN Eteplirsen Study Group
Jun 10, 2014·Frontiers in Immunology·Lillian Cohn, Lélia Delamarre
Jul 6, 2014·The British Journal of Ophthalmology·David S BoyerUNKNOWN V.I.S.I.O.N. Study Group
Mar 5, 2015·Virus Research·Dong Yang, Julian L Leibowitz
Jun 24, 2015·Viruses·John B Presloid, Isabel S Novella
Sep 5, 2015·Orphanet Journal of Rare Diseases·Ole B SuhrDavid Adams
Feb 28, 2016·Nucleic Acids Research·Nicole LudwigAndreas Keller
Sep 1, 2016·Journal of Clinical Lipidology·Frederick J RaalJohn J Kastelein
Mar 1, 2017·Nature Biotechnology·Anastasia Khvorova, Jonathan K Watts
May 31, 2017·Frontiers in Microbiology·Patrice BruscellaMichele Trabucchi
Jul 1, 2017·Science Translational Medicine·Timothy P SheahanRalph S Baric

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Citations

Dec 17, 2020·Epigenomics·Celeste Brady
Oct 24, 2020·Viruses·Kenneth Lundstrom
Oct 23, 2020·Clinical Epigenetics·Sandra AtlanteCarlo Gaetano
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yaroslav StaroseletzMarina Zenkova
Apr 3, 2021·Frontiers in Pharmacology·Zhili TianLei Zhang
May 5, 2021·Molecular Pharmaceutics·Muhammad Imran SajidRakesh K Tiwari
May 29, 2021·NAR Genomics and Bioinformatics·Ryan J AndrewsWalter N Moss
Aug 24, 2021·Immunobiology·Juliana M SerpeloniLuciane R Cavalli

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Datasets Mentioned

BETA
AY278488

Methods Mentioned

BETA
antisense oligonucleotide
antisense oligonucleotides
antisense

Clinical Trials Mentioned

NCT02410733
NCT04283461

Software Mentioned

PITA
GeneGlobe

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