Potential usefulness of single nucleotide polymorphisms to identify persons at high cancer risk: an evaluation of seven common cancers.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Ju-Hyun ParkNilanjan Chatterjee

Abstract

To estimate the likely number and predictive strength of cancer-associated single nucleotide polymorphisms (SNPs) that are yet to be discovered for seven common cancers. From the statistical power of published genome-wide association studies, we estimated the number of undetected susceptibility loci and the distribution of effect sizes for all cancers. Assuming a log-normal model for risks and multiplicative relative risks for SNPs, family history (FH), and known risk factors, we estimated the area under the receiver operating characteristic curve (AUC) and the proportion of patients with risks above risk thresholds for screening. From additional prevalence data, we estimated the positive predictive value and the ratio of non-patient cases to patient cases (false-positive ratio) for various risk thresholds. Age-specific discriminatory accuracy (AUC) for models including FH and foreseeable SNPs ranged from 0.575 for ovarian cancer to 0.694 for prostate cancer. The proportions of patients in the highest decile of population risk ranged from 16.2% for ovarian cancer to 29.4% for prostate cancer. The corresponding false-positive ratios were 241 for colorectal cancer, 610 for ovarian cancer, and 138 or 280 for breast cancer in women...Continue Reading

References

Jul 31, 1975·The New England Journal of Medicine·S G Pauker, J P Kassirer
Sep 24, 1999·Journal of the National Cancer Institute·J P CostantinoH S Wieand
Mar 10, 2001·Journal of the National Cancer Institute·B RockhillG A Colditz
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas S FrankGregory C Critchfield
May 2, 2002·Nature Genetics·Paul D P PharoahBruce A J Ponder
Mar 18, 2005·Biostatistics·Mitchell H Gail, Ruth M Pfeiffer
Jul 7, 2005·Journal of the National Cancer Institute·Joel L WeissfeldUNKNOWN PLCO Project Team
Nov 14, 2006·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Andrew J Vickers, Elena B Elkin
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xifeng WuMargaret R Spitz
Jan 18, 2008·The New England Journal of Medicine·S Lilly ZhengHenrik Grönberg
Apr 22, 2008·American Journal of Human Genetics·Arpita GhoshFred A Wright
Jun 27, 2008·The New England Journal of Medicine·Paul D P PharoahBruce A J Ponder
Jul 10, 2008·Journal of the National Cancer Institute·Mitchell H Gail
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew N FreedmanRuth M Pfeiffer
Mar 20, 2009·The New England Journal of Medicine·Gerald L AndrioleUNKNOWN PLCO Project Team
Jun 19, 2009·Journal of the National Cancer Institute·Mitchell H Gail
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Aug 4, 2009·Annals of the New York Academy of Sciences·Stefan Kohlbecher, Erich Schneider
Jan 14, 2010·Journal of the Royal Statistical Society. Series A, (Statistics in Society)·Stuart G BakerBarnett S Kramer
Mar 20, 2010·The New England Journal of Medicine·Sholom WacholderDavid J Hunter
Jun 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zsofia K StadlerKenneth Offit
Aug 6, 2010·Nature·Tanya M TeslovichSekar Kathiresan
Dec 16, 2010·Biometrics·R M Pfeiffer, M H Gail
Jan 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nilanjan ChatterjeeMitchell H Gail
Jan 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Moniek van ZitterenA Cecile J W Janssens
Feb 18, 2011·International Journal of Cancer. Journal International Du Cancer·Mattias JohanssonPär Stattin

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Citations

May 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Sandya LiyanarachchiAlbert de la Chapelle
Jan 18, 2013·World Journal of Gastroenterology : WJG·Ren-Yin ChenYu-Feng Zhang
Oct 30, 2013·Genetic Epidemiology·Jincao WuMitchell H Gail
Jul 19, 2015·Gut·Ulrike PetersNiha Zubair
Sep 3, 2013·Journal of Surgical Oncology·John K FieldStephen W Duffy
Apr 16, 2015·Hereditary Cancer in Clinical Practice·Michael J HallVeda N Giri
May 4, 2016·Nature Reviews. Genetics·Nilanjan ChatterjeeMontserrat García-Closas
Oct 5, 2016·American Journal of Epidemiology·Merlise A ClydeUNKNOWN , on behalf of the Ovarian Cancer Association Consortium
Apr 4, 2017·Epidemiology·Duncan C Thomas
Mar 1, 2018·Journal of the National Cancer Institute·Mitchell H Gail, Ruth M Pfeiffer
Mar 26, 2019·Biometrical Journal. Biometrische Zeitschrift·Martin SchumacherMonika Engelhardt
May 22, 2013·Nature Reviews. Urology·Helena Furberg, Bernard H Bochner
Mar 1, 2013·Current Obstetrics and Gynecology Reports·Gretchen L GierachMark E Sherman
Jun 20, 2020·Statistical Methods in Medical Research·Mitchell H Gail, David Pee
Apr 5, 2018·Frontiers in Public Health·Mohammed A I Al-ObaideAbdel-Salam G Abdel-Salam

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