Potential utility of soluble p3-alcadein α plasma levels as a biomarker for sporadic Alzheimer's disease

Journal of Alzheimer's Disease : JAD
Kenji KamogawaToshiharu Suzuki

Abstract

Alcadeins (Alcs) constitute a family of neuronal type I membrane proteins (α, β, γ) that share identical localization and function to the amyloid-β protein precursor (AβPP) in the brain. Alcs are proteolyzed in neurons through successive cleavages via secretases, resulting in non-aggregative p3-Alc, where p3 corresponds to the AβPP-fragment. We found p3-Alcα detected in human plasma reflected the pathological process of amyloid-β accumulation in Alzheimer's disease (AD) patients and therefore investigated the utility of p3-Alcα as a plasma biomarker in AD. We measured p3-Alcα plasma levels in 83 sporadic-AD, 18 mild cognitive impaired (MCI), and 24 control subjects using the sandwich-ELISA system. Pooled samples with previously published data (171 AD and 45 controls) were also analyzed. The plasma p3-Alcα concentrations in patients with AD and MCI were significantly higher compared with control subjects (224.7 ± 40.4, 223.3 ± 53.9, and 189.1 ± 32.9 pg/ml, respectively; p = 0.0012). In AD patients, the plasma p3-Alcα concentration significantly correlated with age (r = 0.23, p = 0.037) and serum creatinine levels (r = 0.23, p = 0.0012). Even after adjusting for confounding factors of age, gender, renal function, and ApoE-ε4, hig...Continue Reading

Citations

Sep 4, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Saori Hata
Oct 22, 2016·Journal of Alzheimer's Disease : JAD·Erik PorteliusLaurent Meijer
Nov 23, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Saori HataToshiharu Suzuki

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